The multifaceted roles of matrix metalloproteinases in lung cancer

被引：12
作者：
Wei, Cui [1 ]
机构：
[1] Third Hosp Changsha, Dept Emergency, Changsha, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
关键词：
MMP; lung cancer; tumor immunity; drug resistance; MMP polymorphisms; TUMOR-ASSOCIATED MACROPHAGES; SINGLE NUCLEOTIDE POLYMORPHISM; PROMOTER POLYMORPHISMS; UP-REGULATION; IN-VITRO; FUNCTIONAL POLYMORPHISM; MMP-2; POLYMORPHISMS; GENE POLYMORPHISMS; COLORECTAL-CANCER; CELL-MIGRATION;
D O I：
10.3389/fonc.2023.1195426
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BackgroundThough the matrix metalloproteinases (MMPs) are widely investigated in lung cancer (LC), however, almost no review systematically clarify their multi-faced roles in LC.MethodsWe investigated the expression of MMPs and their effects on survival of patients with LC, the resistance mechanisms of MMPs in anti-tumor therapy, the regulatory networks of MMPs involved, the function of MMPs inducing CSCLs, MMPs-related tumor immunity, and effects of MMP polymorphisms on risk of LC.ResultsHigh expression of MMPs was mainly related to poor survival, high clinical stages and cancer metastasis. Role of MMPs in LC are multi-faced. MMPs are involved in drug resistance, induced CSCLs, participated in tumor immunity. Besides, MMPs polymorphisms may increase risk of LC.ConclusionsMMPs might be promising targets to restore the anti-tumor immune response and enhance the killing function of nature immune cells in LC.
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页数：22
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