The multifaceted roles of matrix metalloproteinases in lung cancer

被引：12
作者：
Wei, Cui [1 ]
机构：
[1] Third Hosp Changsha, Dept Emergency, Changsha, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
关键词：
MMP; lung cancer; tumor immunity; drug resistance; MMP polymorphisms; TUMOR-ASSOCIATED MACROPHAGES; SINGLE NUCLEOTIDE POLYMORPHISM; PROMOTER POLYMORPHISMS; UP-REGULATION; IN-VITRO; FUNCTIONAL POLYMORPHISM; MMP-2; POLYMORPHISMS; GENE POLYMORPHISMS; COLORECTAL-CANCER; CELL-MIGRATION;
D O I：
10.3389/fonc.2023.1195426
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BackgroundThough the matrix metalloproteinases (MMPs) are widely investigated in lung cancer (LC), however, almost no review systematically clarify their multi-faced roles in LC.MethodsWe investigated the expression of MMPs and their effects on survival of patients with LC, the resistance mechanisms of MMPs in anti-tumor therapy, the regulatory networks of MMPs involved, the function of MMPs inducing CSCLs, MMPs-related tumor immunity, and effects of MMP polymorphisms on risk of LC.ResultsHigh expression of MMPs was mainly related to poor survival, high clinical stages and cancer metastasis. Role of MMPs in LC are multi-faced. MMPs are involved in drug resistance, induced CSCLs, participated in tumor immunity. Besides, MMPs polymorphisms may increase risk of LC.ConclusionsMMPs might be promising targets to restore the anti-tumor immune response and enhance the killing function of nature immune cells in LC.
引用
收藏
页数：22
相关论文
共 155 条
  • [91] Expression analysis of three miRNAs, miR-26a, miR-29b and miR-519d, in relation to MMP-2 expression level in non-small cell lung cancer patients: a pilot study
    Pastuszak-Lewandoska, D.
    Kordiak, J.
    Czarnecka, K. H.
    Migdalska-Sek, M.
    Nawrot, E.
    DomanSka-Senderowska, D.
    Kiszalkiewicz, J. M.
    Antczak, A.
    Gorski, P.
    Brzezianska-Lasota, E.
    [J]. MEDICAL ONCOLOGY, 2016, 33 (08)
  • [92] Meta-analysis of association between matrix metalloproteinases 2, 7 and 9 promoter polymorphisms and cancer risk
    Peng, Bo
    Cao, Lihuan
    Ma, Xiaopin
    Wang, Wenzhang
    Wang, Dan
    Yu, Long
    [J]. MUTAGENESIS, 2010, 25 (04) : 371 - 379
  • [93] Membrane-Type 6 Matrix Metalloproteinase Regulates the Activation-Induced Downmodulation of CD16 in Human Primary NK Cells
    Peruzzi, Giovanna
    Femnou, Laurette
    Gil-Krzewska, Aleksandra
    Borrego, Francisco
    Weck, Jennifer
    Krzewski, Konrad
    Coligan, John E.
    [J]. JOURNAL OF IMMUNOLOGY, 2013, 191 (04) : 1883 - 1894
  • [94] Resveratrol sensitizes lung cancer cell to TRAIL by p53 independent and suppression of Akt/NF-κB signaling
    Rasheduzzaman, Mohammad
    Jeong, Jae-Kyo
    Park, Sang-Youel
    [J]. LIFE SCIENCES, 2018, 208 : 208 - 220
  • [95] Matrix Metalloproteinase-10 Promotes Kras-Mediated Bronchio-Alveolar Stem Cell Expansion and Lung Cancer Formation
    Regala, Roderick P.
    Justilien, Verline
    Walsh, Michael P.
    Weems, Capella
    Khoor, Andras
    Murray, Nicole R.
    Fields, Alan P.
    [J]. PLOS ONE, 2011, 6 (10):
  • [96] IL-17A Promotes the Migration and Invasiveness of Colorectal Cancer Cells Through NF-κB-Mediated MMP Expression
    Ren, Hongtao
    Wang, Zhongwei
    Zhang, Shuqun
    Ma, Hongbing
    Wang, Yali
    Jia, Lijun
    Li, Yiming
    [J]. ONCOLOGY RESEARCH, 2016, 23 (05) : 249 - 256
  • [97] Influence of MMP-2 and MMP-9 promoter polymorphisms on gene expression and clinical outcome of non-small cell lung cancer
    Rollin, Jerome
    Regina, Sandra
    Vourc'h, Patrick
    Iochmann, Sophie
    Blechet, Claire
    Reverdiau, Pascale
    Gruel, Yves
    [J]. LUNG CANCER, 2007, 56 (02) : 273 - 280
  • [98] Activation of D2 Dopamine Receptors in CD133+ve Cancer Stem Cells in Non-small Cell Lung Carcinoma Inhibits Proliferation, Clonogenic Ability, and Invasiveness of These Cells
    Roy, Soumyabrata
    Lu, Kai
    Nayak, Mukti Kant
    Bhuniya, Avishek
    Ghosh, Tithi
    Kundu, Suman
    Ghosh, Sarbari
    Baral, Rathindranath
    Dasgupta, Partha Sarathi
    Basu, Sujit
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (02) : 435 - 445
  • [99] Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) prognostic value in lung adenocarcinoma
    Ruiz-Morales, Jose Manuel
    Dorantes-Heredia, Rita
    Arrieta, Oscar
    Chavez-Tapia, Norberto C.
    Motola-Kuba, Daniel
    [J]. TUMOR BIOLOGY, 2015, 36 (05) : 3601 - 3610
  • [100] Safranek J, 2009, ANTICANCER RES, V29, P2513
567891011121314