DNA-Encoded Libraries and Their Application to RNA

被引：4

作者：

Yang, Xueyi ^{[1
,2
]}

Childs-Disney, Jessica L. ^{[1
,2
]}

Paegel, M. ^{[3
]}

Disney, Matthew D. ^{[1
,2
]}

机构：

[1] Herbert Wertheim UF Scripps Inst Biomed Innovat &, Dept Chem, 130 Scripps Way, Jupiter, FL 33458 USA

[2] Scripps Res Inst, 130 Scripps Way, Jupiter, FL 33458 USA

[3] Univ Calif Irvine, Dept Chem & Pharmaceut Sci, Irvine, CA 92617 USA

来源：

ISRAEL JOURNAL OF CHEMISTRY | 2023年 / 63卷 / 10-11期

基金：

美国国家卫生研究院;

关键词：

RNA; DNA-encoded library; drug discovery; small molecules; SMALL-MOLECULE; COMBINATORIAL LIBRARIES; SECONDARY STRUCTURE; LIGAND-BINDING; G-QUADRUPLEX; DISCOVERY; SELECTION; DESIGN; IDENTIFICATION; INHIBITION;

D O I：

10.1002/ijch.202300073

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The functional roles of structured RNAs in the regulation of biological processes, and hence RNA's potential as an effective therapeutic target, have only recently been appreciated. Robust and high-throughput methods that identify potent RNA ligands are critical to the development of chemical probes and therapeutics. DNA-encoded libraries (DEL) technology has emerged as a powerful tool for protein ligand discovery, and its ability to generate large, custom-tailored, and novel chemical space offers unprecedented opportunities to discover the rules of RNA ligand design. In this review, we discuss the basic principles of DEL selection, current progress on the application of DEL to RNA targets, and the outlook of targeting RNA by DEL.

引用

页数：12

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