Prevalence and Correlations of Gastrointestinal Symptoms With Endoscopic and Histologic Mucosal Healing in Crohn's Disease

被引：5

作者：

Tse, Chung Sang ^{[1
]}

Singh, Siddharth ^{[2
]}

Valasek, Mark A. ^{[3
]}

Neill, Jennifer ^{[2
]}

Le, Helen ^{[2
]}

Collins, Angelina E. ^{[2
]}

Boland, Brigid Sweeney ^{[2
]}

机构：

[1] Univ Penn, Div Gastroenterol, Philadelphia, PA 19104 USA

[2] Univ Calif San Diego, Div Gastroenterol, San Diego, CA USA

[3] Univ Calif San Diego, Dept Pathol, San Diego, CA USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2023年 / 118卷 / 04期

关键词：

D O I：

10.14309/ajg.0000000000002122

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

To characterize the associations between clinical disease activity with endoscopic and histologic (endohistologic) mucosal healing in Crohn's disease, we performed a secondary analysis of prospectively collected data on 424 ileocolonoscopies from 258 unique adults at a tertiary referral center from 2014 to 2021. One-third of patients (34%, 25/73) in endoscopic-histologic remission reported gastrointestinal symptoms. The 2-item patient-reported outcome measure for abdominal pain and stool frequency correlated weakly with endoscopic (Simple Endoscopic Score for Crohn's Disease; r = 0.17, 95% CI 0.08-0.26, P = 0.0003) and histologic disease activity (Global Histologic Disease Activity Score; r = 0.14, 95% CI 0.03-0.24, P = 0.015). Overall, gastrointestinal symptoms correlate poorly with endohistologic disease activity.

引用

页码：748 / 751

页数：4

共 12 条

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