Extracellular Vesicles: The Future of Diagnosis in Solid Organ Transplantation?

被引：3

作者：

Romero-Garcia, Nekane ^{[1
,2
,3
,4
]}

Huete-Acevedo, Javier ^{[1
,2
,3
]}

Mas-Bargues, Cristina ^{[1
,2
,3
]}

Sanz-Ros, Jorge ^{[1
,2
,3
,5
]}

Dromant, Mar ^{[1
,2
,3
]}

Badenes, Rafael ^{[4
]}

Borras, Consuelo ^{[1
,2
,3
]}

机构：

[1] Univ Valencia, Fac Med, Dept Physiol, Freshage Res Grp, Valencia 46010, Spain

[2] Inst Salud Carlos III, Ctr Invest Biomed Red Fragil & Envejecimiento Sal, CIBERFES, Madrid 28029, Spain

[3] Inst Sanitario Invest INCLIVA, Valencia 46010, Spain

[4] Univ Valencia, Hosp Clin Univ Valencia, Dept Anesthesiol & Surg Trauma Intens Care, Valencia 46010, Spain

[5] Hosp Univ & Politecn La Fe, Dept Cardiol, Valencia 46026, Spain

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 06期

基金：

英国科研创新办公室;

关键词：

transplant; exosomes; diagnostic; KIDNEY-TRANSPLANTATION; MESSENGER-RNA; GRAFT-SURVIVAL; LONG-TERM; EXOSOMES; REJECTION; MICROPARTICLES; MICROVESICLES; BIOMARKER; HEART;

D O I：

10.3390/ijms24065102

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Solid organ transplantation (SOT) is a life-saving treatment for end-stage organ failure, but it comes with several challenges, the most important of which is the existing gap between the need for transplants and organ availability. One of the main concerns in this regard is the lack of accurate non-invasive biomarkers to monitor the status of a transplanted organ. Extracellular vesicles (EVs) have recently emerged as a promising source of biomarkers for various diseases. In the context of SOT, EVs have been shown to be involved in the communication between donor and recipient cells and may carry valuable information about the function of an allograft. This has led to an increasing interest in exploring the use of EVs for the preoperative assessment of organs, early postoperative monitoring of graft function, or the diagnosis of rejection, infection, ischemia-reperfusion injury, or drug toxicity. In this review, we summarize recent evidence on the use of EVs as biomarkers for these conditions and discuss their applicability in the clinical setting.

引用

页数：21