Identification, classification and expression analysis of the Ras superfamily genes in the Pacific white shrimp, Litopenaeus vannamei

被引:1
作者
Si, Shuqing [1 ,2 ,3 ]
Zhang, Xiaojun [1 ,2 ,3 ,4 ,5 ]
Yuan, Jianbo [2 ,3 ,4 ,5 ]
Zhang, Xiaoxi [2 ,3 ,4 ,5 ]
Yu, Yang [2 ,3 ,4 ,5 ]
Yang, Song [1 ]
Li, Fuhua [2 ,3 ,4 ,5 ]
机构
[1] Qingdao Agr Univ, Sch Life & Sci, Qingdao, Peoples R China
[2] Inst Oceanol, Chinese Acad Sci, Qingdao, Peoples R China
[3] Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
[4] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
[5] Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Peoples R China
基金
国家重点研发计划;
关键词
Ras superfamily; GTPase proteins; Litopenaeus vannamei; gene structure and function; gene expression; immunity; growth; SMALL GTPASES; NEURONAL DIFFERENTIATION; ACTIVATING PROTEINS; CRYSTAL-STRUCTURE; RHO-GTPASES; FAMILY; TRANSPORT; PHAGOCYTOSIS; COMPLEX; MEMBER;
D O I
10.3389/fmars.2023.1063857
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The Ras superfamily of small guanosine triphosphatases (GTPases) are a large group of small GTP-binding proteins, which play crucial roles in basic cellular processes in all eukaryotes. In this study, by analyzing the gene structure, temporal and spatial expression patterns, a total of 108 Ras superfamily genes were identified in the genome of the Pacific white shrimp Litopenaeus vannamei. We found these genes included not only the classical Ras GTPase superfamily members, but also some unconventional and novel Ras GTPase proteins, which have unknown functions and unique expression patterns. All Ras superfamily genes of L. vannamei were highly conserved within the core G domain and closely related in phylogeny, but they might have two different evolutionary origins. In addition, different Ras GTPase genes exhibited distinct expression patterns in different tissues, development/molting stages and WSSV infection samples of L. vannamei, suggesting that they may have a high functional specialization, and play important roles in regulating the biological processes of cell differentiation, growth and development, immune response, etc. This study provides important clues for the structure, classification, evolution and function of Ras superfamily in shrimp.
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页数:17
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