Incidence and outcomes of kidney replacement therapy for end-stage kidney disease due to primary glomerular disease in Europe: findings from the ERA Registry

被引：6

作者：

Abd ElHafeez, Samar ^{[1
,2
]}

Kramer, Anneke ^{[1
,3
,4
]}

Arici, Mustafa ^{[5
]}

Arnol, Miha ^{[6
,7
]}

Asberg, Anders ^{[8
]}

Bell, Samira ^{[9
,10
]}

Belliere, Julie ^{[11
]}

Diaz Corte, Carmen ^{[12
]}

Fernandez Fresnedo, Gema ^{[13
]}

Hemmelder, Marc ^{[14
,15
]}

Heylen, Line ^{[16
,17
,18
]}

Hommel, Kristine ^{[19
]}

Kerschbaum, Julia ^{[20
]}

Naumovic, Radomir ^{[21
]}

Nitsch, Dorothea ^{[22
,23
]}

Santamaria, Rafael ^{[24
,25
]}

Finne, Patrik ^{[26
]}

Palsson, Runolfur ^{[27
,28
]}

Pippias, Maria ^{[29
,30
]}

Resic, Halima ^{[31
]}

Rosenberg, Mai ^{[32
]}

Santiuste de Pablos, Carmen ^{[33
,34
]}

Segelmark, Marten ^{[35
,36
]}

Schwartz Sorensen, Soren ^{[37
]}

Jose Soler, Maria ^{[38
]}

Vidal, Enrico ^{[39
,40
]}

Jager, Kitty J. ^{[1
,3
,4
]}

Ortiz, Alberto ^{[41
,42
]}

Stel, Vianda S. ^{[1
,3
,4
]}

机构：

[1] Amsterdam UMC Locat Univ Amsterdam, Dept Med Informat, ERA Registry, Amsterdam, Netherlands

[2] Alexandria Univ, High Inst Publ Hlth, Epidemiol Dept, Alexandria, Egypt

[3] Amsterdam Publ Hlth, Qual Care, Amsterdam, Netherlands

[4] Ageing & Later Life, Amsterdam, Netherlands

[5] Hacettepe Univ, Fac Med, Dept Nephrol, Ankara, Turkiye

[6] Univ Med Ctr Ljubljana, Dept Nephrol, Ljubljana, Slovenia

[7] Univ Ljubljana, Med Fac, Ljubljana, Slovenia

[8] Oslo Univ Hosp, Dept Transplantat Med, Norwegian Renal Registry, Rikshosp, Oslo, Norway

[9] Scottish Renal Registry, Meridian Court, Glasgow, Scotland

[10] Univ Dundee, Div Populat Hlth & Genom, Dundee, Scotland

[11] Univ Hosp Toulouse, Referral Ctr Rare Kidney Dis, Dept Nephrol & Organ Transplantat, Toulouse, France

[12] Oviedo Univ, Hosp Univ Cent Asturias, Dept Nephrol, Oviedo, Spain

[13] Hosp Univ Marques de Valdecilla, Serv Nefrol, Cantabria, Spain

[14] Maastricht Univ, Med Ctr, Dept Internal Med, Div Nephrol, Maastricht, Netherlands

[15] Univ Maastricht, CARIM Sch Cardiovasc Dis, Maastricht, Netherlands

[16] Dutch Speaking Belgian Renal Registry NBVN, St Niklaas, Belgium

[17] Ziekenhuis Oost Limburg, Dienst Nefrol, Genk, Belgium

[18] Univ Hasselt, Hasselt, Belgium

[19] Holbaek Cent Hosp, Nephrol Dept, Holbaek, Denmark

[20] Med Univ Innsbruck, Dept Internal Med Nephrol & Hypertens 4, Austrian Dialysis & Transplant Registry, Innsbruck, Austria

[21] Univ Belgrade, Med Sch, Belgrade, Serbia

[22] London Sch Hyg & Trop Med, London, England

[23] UK Renal Assoc, Bristol, England

[24] Andalusian Autonomous Transplant Coordinat Inform, Seville, Spain

[25] Reina Sofia Univ Hosp, Nephrol Serv, Cordoba, Spain

[26] Univ Helsinki, Cent Hosp, Div Nephrol, Helsinki, Finland

[27] Landspitali The Natl Univ Hosp Iceland, Div Nephrol, Reykjavik, Iceland

[28] Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland

[29] Univ Bristol, Dept Hlth Care Evaluat, Populat Hlth Sci, Bristol, England

[30] North Bristol NHS Trust, Bright Renal Unit, Bristol, England

[31] Univ Sarajevo, Clin Ctr, Clin Hemodialysis Sarajevo, Renal Registry Soc Nephrol Dialysis & Transplanta, Sarajevo, Bosnia & Herceg

[32] Tartu Univ Hosp, Competence Ctr Rare Dis, Tartu, Estonia

[33] Murcia Reg Hlth Council, Murcia Renal Registry, IMIB Arrixaca, Dept Epidemiol, Murcia, Spain

[34] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain

[35] Lund Univ, Dept Clin Sci, Div Nephrol, Lund, Sweden

[36] Skane Univ Hosp, Dept Endocrinol Nephrol & Rheumatol, Lund, Sweden

[37] Copenhagen Univ Hosp, Rigshosp, Dept Nephrol, Copenhagen, Denmark

[38] Vall dHebron Univ Hosp, Dept Nephrol, Barcelona, Spain

[39] Univ Udine, Dept Med DAME, Udine, Italy

[40] Univ Hosp Padova, Pediat Nephrol Unit, Padua, Italy

[41] IIS Fdn Jimenez Diaz UAM, Dept Nephrol & Hypertens, Madrid, Spain

[42] Univ Autonoma Madrid, Dept Med, Madrid, Spain

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2024年 / 39卷 / 09期

关键词：

dialysis; epidemiology; kidney replacement therapy; outcome; primary glomerular disease; PRIMARY GLOMERULONEPHRITIS; RENAL-DISEASE; PERITONEAL-DIALYSIS; IGA NEPHROPATHY; BIOPSY; EPIDEMIOLOGY; PROGRESSION; TRENDS; PROGNOSIS; WORLDWIDE;

D O I：

10.1093/ndt/gfae034

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Background Primary glomerular disease (PGD) is a major cause of end-stage kidney disease (ESKD) leading to kidney replacement therapy (KRT). We aimed to describe incidence (trends) in individuals starting KRT for ESKD due to PGD and to examine their survival and causes of death.Methods We used data from the European Renal Association (ERA) Registry on 69 854 patients who started KRT for ESKD due to PGD between 2000 and 2019. ERA primary renal disease codes were used to define six PGD subgroups. We examined age and sex standardized incidence, trend of the incidence and survival.Results The standardized incidence of KRT for ESKD due to PGD was 16.6 per million population (pmp), ranging from 8.6 pmp in Serbia to 20.0 pmp in France. Immunoglobulin A nephropathy (IgAN) and focal segmental glomerulosclerosis (FSGS) had the highest incidences, of 4.6 pmp and 2.6 pmp, respectively. Histologically non-examined PGDs represented over 50% of cases in Serbia, Bosnia and Herzegovina, and Romania and were also common in Greece, Estonia, Belgium and Sweden. The incidence declined from 18.6 pmp in 2000 to 14.5 pmp in 2013, after which it stabilized. All PGD subgroups had 5-year survival probabilities above 50%, with crescentic glomerulonephritis having the highest risk of death [adjusted hazard ratio 1.8 (95% confidence interval 1.6-1.9)] compared with IgAN. Cardiovascular disease was the most common cause of death (33.9%).Conclusion The incidence of KRT for ESKD due to PGD showed large differences between countries and was highest and increasing for IgAN and FSGS. Lack of kidney biopsy facilities in some countries may have affected accurate assignment of the cause of ESKD. The recognition of the incidence and outcomes of KRT among different PGD subgroups may contribute to a more individualized patient care approach. Graphical Abstract 10.1093/ndt/gfae034 Video Watch the video of this contribution at https://academic.oup.com/ndt/pages/author_videos gfae034Media1 6347328784112

引用

页码：1449 / 1460

页数：12

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