Developing New Strategies for Relapsed/Refractory Diffuse Large B-Cell Lymphoma

被引：5

作者：

Barca, Eva Gonzalez ^{[1
]}

机构：

[1] Univ Barcelona, Catalan Inst Oncol, Hematol Dept, IDIBELL, Barcelona 08908, Spain

来源：

JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 23期

关键词：

diffuse large B-cell lymphoma; relapsed/refractory; therapy; efficacy; toxicity; SINGLE-ARM; BRENTUXIMAB VEDOTIN; OPEN-LABEL; PHASE-III; R-CHOP; RITUXIMAB; LENALIDOMIDE; MULTICENTER; PREDNISONE; IBRUTINIB;

D O I：

10.3390/jcm12237376

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diffuse large B-cell lymphoma (DLBCL) is an aggressive and biologically heterogeneous disease. Approximately 40% of patients with DLBCL will experience disease relapse or will be refractory to first-line chemo immunotherapy. In recent years, there have been several new therapeutic agents approved for the treatment of relapsed/refractory (R/R) DLBCL. These agents include anti-CD19 chimeric antigen receptor T-cell (CAR T-cell) and monoclonal antibody therapies such as polatuzumab and tafasitamab. Nevertheless, despite the high efficacy of all these new therapies, there are still patients who do not respond or relapse, representing an unmet clinical need. This review describes new promising therapies that are in clinical development to treat R/R DLBCL.

引用

页数：12

共 50 条

[1] Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study [J].

Abramson, Jeremy S. ;

Palomba, M. Lia ;

Gordon, Leo I. ;

Lunning, Matthew A. ;

Wang, Michael ;

Arnason, Jon ;

Mehta, Amitkumar ;

Purev, Enkhtsetseg ;

Maloney, David G. ;

Andreadis, Charalambos ;

Sehgal, Alison ;

Solomon, Scott R. ;

Ghosh, Nilanjan ;

Albertson, Tina M. ;

Garcia, Jacob ;

Kostic, Ana ;

Mallaney, Mary ;

Ogasawara, Ken ;

Newhall, Kathryn ;

Kim, Yeonhee ;

Li, Daniel ;

Siddiqi, Tanya .

LANCET, 2020, 396 (10254) :839-852

[2] CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Lymphoma [J].

Advani, Ranjana ;

Flinn, Ian ;

Popplewell, Leslie ;

Forero, Andres ;

Bartlett, Nancy L. ;

Ghosh, Nilanjan ;

Kline, Justin ;

Roschewski, Mark ;

LaCasce, Ann ;

Collins, Graham P. ;

Thu Tran ;

Lynn, Judith ;

Chen, James Y. ;

Volkmer, Jens-Peter ;

Agoram, Balaji ;

Huang, Jie ;

Majeti, Ravindra ;

Weissman, Irving L. ;

Takimoto, Chris H. ;

Chao, Mark P. ;

Smith, Sonali M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (18) :1711-1721

[3] Odronextamab, a human CD20xCD3 bispecific antibody in patients with CD20-positive B-cell malignancies (ELM-1): results from the relapsed or refractory non-Hodgkin lymphoma cohort in a single-arm, multicentre, phase 1 trial [J].

Bannerji, Rajat ;

Arnason, Jon E. ;

Advani, Ranjana H. ;

Brown, Jennifer R. ;

Allan, John N. ;

Ansell, Stephen M. ;

Barnes, Jeffrey A. ;

O'Brien, Susan M. ;

Chavez, Julio C. ;

Duell, Johannes ;

Rosenwald, Andreas ;

Crombie, Jennifer L. ;

Ufkin, Melanie ;

Li, Jingjin ;

Zhu, Min ;

Ambati, Srikanth R. ;

Chaudhry, Aafia ;

Lowy, Israel ;

Topp, Max S. .

LANCET HAEMATOLOGY, 2022, 9 (05) :E327-E339

[4] Second-Line Tisagenlecleucel or Standard Care in Aggressive B-Cell Lymphoma [J].

Bishop, M. R. ;

Dickinson, M. ;

Purtill, D. ;

Barba, P. ;

Santoro, A. ;

Hamad, N. ;

Kato, K. ;

Sureda, A. ;

Greil, R. ;

Thieblemont, C. ;

Morschhauser, F. ;

Janz, M. ;

Flinn, I ;

Rabitsch, W. ;

Kwong, Y-L ;

Kersten, M. J. ;

Minnema, M. C. ;

Holte, H. ;

Chan, E. H. L. ;

Martinez-Lopez, J. ;

Mueller, A. M. S. ;

Maziarz, R. T. ;

McGuirk, J. P. ;

Bachy, E. ;

Le Gouill, S. ;

Dreyling, M. ;

Harigae, H. ;

Bond, D. ;

Andreadis, C. ;

McSweeney, P. ;

Kharfan-Dabaja, M. ;

Newsome, S. ;

Degtyarev, E. ;

Awasthi, R. ;

del Corral, C. ;

Andreola, G. ;

Masood, A. ;

Schuster, S. J. ;

Jaeger, U. ;

Borchmann, P. ;

Westin, J. R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (07) :629-639

[5] The AntiCD19 Antibody Drug Immunoconjugate Loncastuximab Achieves Responses in DLBCL Relapsing After AntiCD19 CAR-T Cell Therapy [J].

Caimi, Paolo F. ;

Ardeshna, Kirit M. ;

Reid, Erin ;

Ai, Weiyun ;

Lunning, Matthew ;

Zain, Jasmine ;

Solh, Melhem ;

Kahl, Brad S. ;

Hamadani, Mehdi .

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2022, 22 (05) :E335-E339

[6] Loncastuximab tesirine in relapsed or refractory diffuse large B-cell lymphoma (LOTIS-2): a multicentre, open-label, single-arm, phase 2 trial [J].

Caimi, Paolo F. ;

Ai, Weiyun ;

Alderuccio, Juan Pablo ;

Ardeshna, Kirit M. ;

Hamadani, Mehdi ;

Hess, Brian ;

Kahl, Brad S. ;

Radford, John ;

Solh, Melhem ;

Stathis, Anastasios ;

Zinzani, Pier Luigi ;

Havenith, Karin ;

Feingold, Jay ;

He, Shui ;

Qin, Yajuan ;

Ungar, David ;

Zhang, Xiaoyan ;

Carlo-Stella, Carmelo .

LANCET ONCOLOGY, 2021, 22 (06) :790-800

[7] Sequential Anti-CD19 Directed Chimeric Antigen Receptor Modified T-Cell Therapy (CART19) and PD-1 Blockade with Pembrolizumab in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphomas [J].

Chong, Elise A. ;

Svoboda, Jakub ;

Nasta, Sunita Dwivedy ;

Landsburg, Daniel J. ;

Winchell, Nicole ;

Napier, Ellen ;

Mato, Anthony R. ;

Melenhorst, J. Joseph ;

Ruella, Marco ;

Lacey, Simon F. ;

June, Carl H. ;

Schuster, Stephen J. .

BLOOD, 2018, 132

[8] CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. [J].

Coiffier, B ;

Lepage, E ;

Brière, J ;

Herbrecht, R ;

Tilly, H ;

Bouabdallah, R ;

Morel, P ;

Van den Neste, E ;

Salles, G ;

Gaulard, P ;

Reyes, F ;

Gisselbrecht, C .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (04) :235-242

[9] Outcomes in refractory diffuse large B-cell lymphoma: results from the international SCHOLAR-1 study [J].

Crump, Michael ;

Neelapu, Sattva S. ;

Farooq, Umar ;

Van den Neste, Eric ;

Kuruvilla, John ;

Westin, Jason ;

Link, Brian K. ;

Hay, Annette ;

Cerhan, James R. ;

Zhu, Liting ;

Boussetta, Sami ;

Feng, Lei ;

Maurer, Matthew J. ;

Navale, Lynn ;

Wiezorek, Jeff ;

Go, William Y. ;

Gisselbrecht, Christian .

BLOOD, 2017, 130 (16) :1800-1808

[10] Glofitamab for Relapsed or Refractory Diffuse Large B-Cell Lymphoma [J].

Dickinson, Michael J. ;

Carlo-Stella, Carmelo ;

Morschhauser, Franck ;

Bachy, Emmanuel ;

Corradini, Paolo ;

Iacoboni, Gloria ;

Khan, Cyrus ;

Wrobel, Tomasz ;

Offner, Fritz ;

Wu, Shang-Ju ;

Cartron, Guillaume ;

Hertzberg, Mark ;

Sureda, Anna ;

Perez-Callejo, David ;

Lundberg, Linda ;

Relf, James ;

Dixon, Mark ;

Clark, Emma ;

Humphrey, Kathryn ;

Hutchings, Martin ;

Trney, Marek .

NEW ENGLAND JOURNAL OF MEDICINE, 2022, 387 (24) :2220-2231

← 1 2 3 4 5 →