Beneficial effects of flavonoids on animal models of atherosclerosis: A systematic review and meta-analysis

被引：7
作者：
Liao, Gege [1 ]
Liu, Wanlu [1 ]
Dai, Yiming [1 ]
Shi, Xiangxiang [2 ]
Liu, Yang [1 ]
Li, Dongye [1 ]
Xu, Tongda [2 ]
机构：
[1] Xuzhou Med Univ, Inst Cardiovasc Dis Res, Xuzhou, Peoples R China
[2] Xuzhou Med Univ, Affiliated Hosp, Dept Cardiol, Xuzhou, Peoples R China
来源：
ISCIENCE | 2023年 / 26卷 / 11期
基金：
中国国家自然科学基金;
关键词：
LOW-DENSITY-LIPOPROTEIN; NF-KAPPA-B; DIET-INDUCED ATHEROSCLEROSIS; HIGH-CHOLESTEROL DIET; E-KNOCKOUT MICE; BINDING CASSETTE TRANSPORTERS; ATTENUATES ATHEROSCLEROSIS; LIPID-PROFILE; OXIDATIVE STRESS; UP-REGULATION;
D O I：
10.1016/j.isci.2023.108337
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Atherosclerosis is the main cause of cardiovascular diseases that seriously endanger human health. The existing treatment drugs are effective, but they have some side effects. Accumulating evidence suggests that flavonoids have attracted wide attention due to their multiple cardioprotective effects and fewer side effects. PubMed, Web of Science database, Embase, and Cochrane Library were searched for studies evaluating the effects of flavonoids against atherosclerosis. 119 studies published from August 1954 to April 2023 were included. Random-effects models were performed for synthesis. Compared with the control group, flavonoids significantly reduced longitudinal and cross-sectional plaque area. The findings indicated that flavonoids significantly reduced the concentrations of serum TC, TG, and LDL-C and increased serum HDL-C concentrations. Besides, flavonoids reduced the levels of circulating pro-inflammatory factors, including TNF-alpha, IL-1 beta, and IL-6, and increased the serum IL-10 level. This study provides evidence for the potential cardiovascular benefits of flavonoids.
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页数：22
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