Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia in Patients Treated With Anti-CD20 Monoclonal Antibodies

被引：4

作者：

Furie, Nadav ^{[1
,2
]}

Mandelboim, Michal ^{[2
,3
,4
]}

Zuckerman, Neta ^{[2
,3
,4
]}

Belkin, Ana ^{[5
,6
]}

Seluk, Lior ^{[1
,2
]}

Shafran, Inbal ^{[1
,2
]}

Mass, Ronen ^{[1
]}

Levy, Liran ^{[1
,2
]}

Chatterji, Sumit ^{[1
]}

Baltaxe, Erik ^{[1
,2
]}

Peled, Michael ^{[1
,2
]}

Shulimzon, Tiberiu ^{[1
]}

Avigdor, Abraham ^{[2
,7
]}

Amit, Sharon ^{[8
]}

Onn, Amir ^{[1
,2
]}

Marom, Edith M. ^{[2
,9
]}

Rahav, Galia ^{[2
,10
]}

Segel, Michael J. ^{[1
,2
,11
]}

机构：

[1] Sheba Med Ctr, Inst Pulmonol, Tel Hashomer, Israel

[2] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel

[3] Minist Hlth, Publ Hlth Serv, Cent Virol Lab, Tel Hashomer, Israel

[4] Sheba Med Ctr, Tel Hashomer, Israel

[5] Sheba Med Ctr, Internal Med D, Tel Hashomer, Israel

[6] Sheba Med Ctr, Infect Dis Unit, Tel Hashomer, Israel

[7] Sheba Med Ctr, Div Hematol & Bone Marrow Transplantat, Ramat Gan, Israel

[8] Sheba Med Ctr, Microbiol Lab, Tel Hashomer, Israel

[9] Sheba Med Ctr, Dept Diagnost Radiol, Tel Hashomer, Israel

[10] Sheba Med Ctr, 2 Derech Sheba, IL-52621 Ramat Gan, Israel

[11] Sheba Med Ctr, Inst Pulmonol, 2 Derech Sheba, IL-52621 Ramat Gan, Israel

来源：

OPEN FORUM INFECTIOUS DISEASES | 2023年 / 10卷 / 10期

关键词：

antibody therapy; COVID19; immune globulins; monoclonal antibody; SARS-CoV-2; SARS-COV-2; THERAPY;

D O I：

10.1093/ofid/ofad464

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report 8 cases of persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia in patients previously treated with anti-CD20 monoclonal antibodies. Polymerase chain reaction of nasopharyngeal swabs for SARS-CoV-2 was negative in most cases; viral cell cultures confirmed that viable SARS-Co-2 virus was present. Four patients were treated with anti-SARS-CoV-2 hyperimmune globulins with rapid resolution of disease.

引用

页数：4

共 11 条

[1] Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer
Avanzato, Victoria A.
Matson, M. Jeremiah
Seifert, Stephanie N.
Pryce, Rhys
Williamson, Brandi N.
Anzick, Sarah L.
Barbian, Kent
Judson, Seth D.
Fischer, Elizabeth R.
Martens, Craig
Bowden, Thomas A.
de Wit, Emmie
Riedo, Francis X.
Munster, Vincent J.
[J]. CELL, 2020, 183 (07) : 1901 - +
[2] Bronchoalveolar lavage-detected SARS-CoV-2 infection in presence of serial negative nasopharyngeal swabs: a case report
Caci, Grazia
Minervini, Fabrizio
Fechner, Carsten
Roos, Justus E.
Obermann, Ellen C.
Azzola, Andrea
[J]. ANNALS OF TRANSLATIONAL MEDICINE, 2021, 9 (07)
[3] Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host
Choi, Bina
Choudhary, Manish C.
Regan, James
Sparks, Jeffrey A.
Padera, Robert F.
Qiu, Xueting
Solomon, Isaac H.
Kuo, Hsiao-Hsuan
Boucau, Julie
Bowman, Kathryn
Das Adhikari, U.
Winkler, Marisa L.
Mueller, Alisa A.
Hsu, Tiffany Y. -T.
Desjardins, Michael
Baden, Lindsey R.
Chan, Brian T.
Walker, Bruce D.
Lichterfeld, Mathias
Brigl, Manfred
Kwon, Douglas S.
Kanjilal, Sanjat
Richardson, Eugene T.
Jonsson, A. Helena
Alter, Galit
Barczak, Amy K.
Hanage, William P.
Yu, Xu G.
Gaiha, Gaurav D.
Seaman, Michael S.
Cernadas, Manuela
Li, Jonathan Z.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (23) : 2291 - 2293
[4] Persistent COVID-19 in an Immunocompromised Patient Temporarily Responsive to Two Courses of Remdesivir Therapy
Helleberg, Marie
Niemann, Carsten Utoft
Moestrup, Kasper Sommerlund
Kirk, Ole
Lebech, Anne-Mette
Lane, Clifford
Lundgren, Jens
[J]. JOURNAL OF INFECTIOUS DISEASES, 2020, 222 (07) : 1103 - 1107
[5] Convalescent plasma therapy for B-cell-depleted patients with protracted COVID-19
Hueso, Thomas
Pouderoux, Cecile
Pere, Helene
Beaumont, Anne-Lise
Raillon, Laure-Anne
Ader, Florence
Chatenoud, Lucienne
Eshagh, Deborah
Szwebel, Tali-Anne
Martinot, Martin
Camou, Fabrice
Crickx, Etienne
Michel, Marc
Mahevas, Matthieu
Boutboul, David
Azoulay, Elie
Joseph, Adrien
Hermine, Olivier
Rouzaud, Claire
Faguer, Stanislas
Petua, Philippe
Pommeret, Fanny
Clerc, Sebastien
Planquette, Benjamin
Merabet, Fatiha
London, Jonathan
Zeller, Valerie
Ghez, David
Veyer, David
Ouedrani, Amani
Gallian, Pierre
Pacanowski, Jerome
Mekinian, Arsene
Garnier, Marc
Pirenne, France
Tiberghien, Pierre
Lacombe, Karine
[J]. BLOOD, 2020, 136 (20) : 2290 - 2295
[6] Neutralizing SARS-CoV-2 Antibodies in Commercial Immunoglobulin Products Give Patients with X-Linked Agammaglobulinemia Limited Passive Immunity to the Omicron Variant
Lindahl, Hannes
Klingstrom, Jonas
Da Silva Rodrigues, Rui
Christ, Wanda
Chen, Puran
Ljunggren, Hans-Gustaf
Buggert, Marcus
Aleman, Soo
Smith, C. I. Edvard
Bergman, Peter
[J]. JOURNAL OF CLINICAL IMMUNOLOGY, 2022, 42 (06) : 1130 - 1136
[7] Real Time PCR and Culture-Based Virus Isolation Test in Clinically Recovered Patients: Is the Subject Still Infectious for SARS-CoV2?
Manzulli, Viviana
Scioscia, Giulia
Giganti, Giulio
Capobianchi, Maria Rosaria
Lacedonia, Donato
Pace, Lorenzo
Cipolletta, Dora
Tondo, Pasquale
De Nittis, Rosella
Rondinone, Valeria
Serrecchia, Luigina
Parisi, Antonio
Galante, Domenico
Lo Caputo, Sergio
Santantonio, Teresa Antonia
Moschetta, Damiana
Dattoli, Vitangelo
Fasanella, Antonio
Foschino Barbaro, Maria Pia
[J]. JOURNAL OF CLINICAL MEDICINE, 2021, 10 (02) : 1 - 10
[8] Hyperimmune immunoglobulin for hospitalised patients with COVID-19 (ITAC): a double-blind, placebo-controlled, phase 3, randomised trial
Polizzotto, Mark N.
Nordwall, Jacqueline
Babiker, Abdel G.
Phillips, Andrew
Vock, David M.
Eriobu, Nnakelu
Kwaghe, Vivian
Paredes, Roger
Mateu, Lourdes
Ramachandruni, Srikanth
Narang, Rajeev
Jain, Manua K.
Lazarte, Susana M.
Baker, Jason, V
Frosch, Anne E. P.
Poulakou, Garyfallia
Syrigos, Konstantinos N.
Amoczy, Gretchen S.
McBride, Natalie A.
Robinson, Philip A.
Sarafian, Farjad
Bhagani, Sanjay
Taha, I. Lassan S.
Benfield, Thomas
Liu, Sean T. H.
Antoniadou, Anastasia
Jensen, Jens Ulrik Staehr
Kalomenidis, Ioannis
Susilo, Adityo
Hariadi, Prasetyo
Jensen, Tomas O.
Morales-Rull, Jose Luis
Helleberg, Marie
Meegada, Sreenath
Johansen, Isik S.
Canario, Daniel
Fernandez-Cruz, Eduardo
Metallidis, Simeon
Shah, Amish
Sakurai, Aki
Koulouris, Nikolaus G.
Trounan, Robin
Weintrob, Amy C.
Podlekareva, Dania
Hadi, Usman
Lloyd, Kathryn M.
Roge, Birgit Thorup
Saito, Sho
Sweenis, Kelly
Malin, Jakob J.
[J]. LANCET, 2022, 399 (10324) : 530 - 540
[9] Consequences of B-cell-depleting therapy: hypogammaglobulinemia and impaired B-cell reconstitution
Sacco, Keith A.
Abraham, Roshini S.
[J]. IMMUNOTHERAPY, 2018, 10 (08) : 713 - 728
[10] Detection of SARS-CoV-2 in Different Types of Clinical Specimens
Wang, Wenling
Xu, Yanli
Gao, Ruqin
Lu, Roujian
Han, Kai
Wu, Guizhen
Tan, Wenjie
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (18): : 1843 - 1844

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