The impact of multifocal perineural invasion in predicting survival in patients with oral squamous cell carcinoma: A multicenter investigation

被引：3
|
作者：
Hasmat, Shaheen [1 ,2 ,9 ]
Heller, Gillian [2 ]
Cook, Lachlan [3 ,4 ,5 ]
Gupta, Ruta [1 ,2 ,6 ]
Clark, Jonathan R. [1 ,2 ,7 ]
Ooi, Eng H. [3 ,4 ,5 ]
Low, Tsu-Hui [1 ,2 ,8 ]
机构：
[1] Univ Sydney, Fac Med & Hlth, Cent Clin Sch, Sydney, NSW, Australia
[2] Sydney Head & Neck Canc Inst, Chris OBrien Lifehouse, Camperdown, NSW, Australia
[3] Flinders Med Ctr, Dept Otolaryngol Head & Neck Surg, Adelaide, SA, Australia
[4] Royal Adelaide Hosp, Adelaide, SA, Australia
[5] Flinders Univ S Australia, Coll Med & Publ Hlth, Dept Surg, Bedford Pk, SA, Australia
[6] Royal Prince Alfred Hosp, Dept Tissue Pathol & Diagnost Oncol, NSW Hlth Pathol, Sydney, NSW, Australia
[7] Sydney Local Hlth Dist, Royal Prince Alfred Inst Acad Surg, Sydney, NSW, Australia
[8] Macquarie Univ, Fac Med & Hlth Sci, Dept Otolaryngol Head & Neck Surg, Sydney, NSW, Australia
[9] Sydney Head & Neck Canc Inst, Chris OBrien Lifehouse, 119-143 Missenden Rd, Camperdown, NSW 2050, Australia
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2023年 / 45卷 / 10期
关键词：
AJCC; oral cancer; perineural invasion; squamous cell carcinoma; survival; AMERICAN JOINT COMMITTEE; PROGNOSTIC IMPACT; CANCER; DEPTH;
D O I：
10.1002/hed.27485
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
BackgroundPerineural invasion (PNI) in oral squamous cell carcinoma (OSCC) does not contribute to the current American Joint Committee on Cancer 8th edition (AJCC8) staging manual. This study seeks to validate the effect of multifocal PNI in a large cohort of patients. MethodsPatients undergoing primary surgical treatment of OSCC with curative intent between 1995 and 2022 was retrieved from two Australian head and neck databases. PNI was categorized as a single focus or multiple foci. Study end points included disease-specific survival (DSS) and overall survival (OS). ResultsComplete data for survival analysis was available in 993 patients. Multifocal PNI was associated with a 61% increased risk of death due to OSCC (HR 1.61, 95% CI 1.11-2.33, p = 0.014) and a 32% increased risk of death from any cause (HR 1.32, 95% CI 1.01-1.73, p = 0.045). ConclusionsMultifocal PNI is a significant predictor of survival in OSCC.
引用
收藏
页码：2605 / 2612
页数：8
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