Role of Tim-3 in COVID-19: a potential biomarker and therapeutic target

被引：2

作者：

Ma, Haodong ^{[1
]}

Ren, Shengju ^{[1
]}

Meng, Qingpeng ^{[1
]}

Su, Boyuan ^{[1
]}

Wang, Kun ^{[1
]}

Liu, YiChen ^{[1
]}

Wang, Junpeng ^{[2
]}

Ding, Degang ^{[2
]}

Li, Xin ^{[1
,3
,4
]}

机构：

[1] Zhengzhou Univ, Sch Basic Med Sci, Dept Pathophysiol, Zhengzhou 450001, Henan, Peoples R China

[2] Zhengzhou Univ Peoples Hosp, Henan Prov Peoples Hosp, Dept Urol, Zhengzhou 450003, Henan, Peoples R China

[3] Zhengzhou Univ, Collaborat Innovat Ctr Henan Prov Canc Chemopreven, Zhengzhou 450001, Henan, Peoples R China

[4] Zhengzhou Univ, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Henan, Peoples R China

来源：

ARCHIVES OF VIROLOGY | 2023年 / 168卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Tim-3; COVID-19; Immune response; T-CELL EXHAUSTION; BLOCKADE; AUTOIMMUNE; RESPONSES; PD-1; EXPRESSION; APOPTOSIS; RESTORES;

D O I：

10.1007/s00705-023-05842-2

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

T cell immunoglobulin and mucin domain containing protein 3 (Tim-3), an immune checkpoint, is important for maintaining immune tolerance. There is increasing evidence that Tim-3 is aberrantly expressed in patients with COVID-19, indicating that it may play an important role in COVID-19. In this review, we discuss the altered expression and potential role of Tim-3 in COVID-19. The expression of Tim-3 and its soluble form (sTim-3) has been found to be upregulated in COVID-19 patients. The levels of Tim-3 on T cells and circulating sTim-3 have been shown to be associated with the severity of COVID-19, suggesting that this protein could be a potential biomarker of COVID-19. Moreover, this review also highlights the potential of Tim-3 as a therapeutic target of COVID-19.

引用

页数：8

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