Role of Tim-3 in COVID-19: a potential biomarker and therapeutic target

被引：2
作者：
Ma, Haodong [1 ]
Ren, Shengju [1 ]
Meng, Qingpeng [1 ]
Su, Boyuan [1 ]
Wang, Kun [1 ]
Liu, YiChen [1 ]
Wang, Junpeng [2 ]
Ding, Degang [2 ]
Li, Xin [1 ,3 ,4 ]
机构：
[1] Zhengzhou Univ, Sch Basic Med Sci, Dept Pathophysiol, Zhengzhou 450001, Henan, Peoples R China
[2] Zhengzhou Univ Peoples Hosp, Henan Prov Peoples Hosp, Dept Urol, Zhengzhou 450003, Henan, Peoples R China
[3] Zhengzhou Univ, Collaborat Innovat Ctr Henan Prov Canc Chemopreven, Zhengzhou 450001, Henan, Peoples R China
[4] Zhengzhou Univ, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Henan, Peoples R China
来源：
ARCHIVES OF VIROLOGY | 2023年 / 168卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Tim-3; COVID-19; Immune response; T-CELL EXHAUSTION; BLOCKADE; AUTOIMMUNE; RESPONSES; PD-1; EXPRESSION; APOPTOSIS; RESTORES;
D O I：
10.1007/s00705-023-05842-2
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
T cell immunoglobulin and mucin domain containing protein 3 (Tim-3), an immune checkpoint, is important for maintaining immune tolerance. There is increasing evidence that Tim-3 is aberrantly expressed in patients with COVID-19, indicating that it may play an important role in COVID-19. In this review, we discuss the altered expression and potential role of Tim-3 in COVID-19. The expression of Tim-3 and its soluble form (sTim-3) has been found to be upregulated in COVID-19 patients. The levels of Tim-3 on T cells and circulating sTim-3 have been shown to be associated with the severity of COVID-19, suggesting that this protein could be a potential biomarker of COVID-19. Moreover, this review also highlights the potential of Tim-3 as a therapeutic target of COVID-19.
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页数：8
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