Pharmacological options in the treatment of osteogenesis imperfecta: A comprehensive review of clinical and potential alternatives

被引：2
|
作者：
Munoz-Garcia, Javier [1 ,2 ]
Heymann, Dominique [1 ,2 ,3 ]
Giurgea, Irina [4 ]
Legendre, Marie [4 ]
Amselem, Serge [4 ]
Castaneda, Beatriz [5 ]
Lezot, Frederic [4 ]
Vargas-Franco, Jorge William [6 ]
机构：
[1] Inst Cancerol Ouest, F-44805 St Herblain, France
[2] Nantes Univ, CNRS, US2B, UMR 6286, F-44322 Nantes, France
[3] Univ Sheffield, Med Sch, Dept Oncol & Metab, Sheffield, England
[4] Sorbonne Univ, Hop Trousseau, AP HP, INSERM UMR933, F-75012 Paris, France
[5] Hop La Pitie Salpetriere, AP HP, Serv Orthope Dento Facial, Dept Odontol, F-75013 Paris, France
[6] Univ Antioquia, Fac Dent, Medellin, Colombia
来源：
BIOCHEMICAL PHARMACOLOGY | 2023年 / 213卷
关键词：
Osteogenesis Imperfecta; Pharmacological Treatment; Bisphosphonates; Antiresorptive Drugs; Anabolic Drugs; INTRAVENOUS PAMIDRONATE TREATMENT; GROWTH-HORMONE TREATMENT; BONE-MINERAL DENSITY; BISPHOSPHONATE TREATMENT; ALENDRONATE TREATMENT; STRONTIUM RANELATE; ZOLEDRONIC ACID; ADULT PATIENTS; FRACTURE RATE; ANTIRESORPTIVE THERAPIES;
D O I：
10.1016/j.bcp.2023.115584
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Osteogenesis imperfecta (OI) is a genetically heterogeneous connective tissue disorder characterized by bone fragility and different extra-skeletal manifestations. The severity of these manifestations makes it possible to classify OI into different subtypes based on the main clinical features.This review aims to outline and describe the current pharmacological alternatives for treating OI, grounded on clinical and preclinical reports, such as antiresorptive agents, anabolic agents, growth hormone, and anti-TGF beta antibody, among other less used agents. The different options and their pharmacokinetic and pharmacodynamic properties will be reviewed and discussed, focusing on the variability of their response and the molecular mechanisms involved to attain the main clinical goals, which include decreasing fracture incidence, improving pain, and promoting growth, mobility, and functional independence.
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页数：15
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