Abrocitinib as a novel treatment for lichen sclerosus

被引：13

作者：

Bao, Chengbei ^{[1
,2
,3
]}

Xu, Qiuyun ^{[1
,2
,3
]}

Xiao, Zhixun ^{[1
,2
,3
]}

Wang, Haiqing ^{[1
,2
,3
]}

Luo, Renwei ^{[1
,2
,3
]}

Cheng, Bo ^{[1
,2
,3
]}

Ji, Chao ^{[1
,2
,3
]}

Gong, Ting ^{[4
]}

机构：

[1] Fujian Med Univ, Dept Dermatol, Affiliated Hosp 1, Fuzhou, Peoples R China

[2] Fujian Med Univ, Affiliated Hosp 1, Fujian Dermatol & Venereol Res Inst, Fuzhou, Peoples R China

[3] Fujian Med Univ, Affiliated Hosp 1, Key Lab Skin Canc Fujian Higher Educ Inst, Fuzhou, Peoples R China

[4] Fujian Med Univ, Cent Lab, Affiliated Hosp 1, Fuzhou, Peoples R China

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2023年 / 189卷 / 01期

关键词：

D O I：

10.1093/bjd/ljad129

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Ten patients were recruited to evaluate the efficacy and safety of abrocitinib for the treatment of lichen sclerosus (LS). All patients reported rapid control of pruritus at week 2 and achieved Investigator's Global Assessment 0 or 1 at week 12. This study suggests that the abrocitinib could be an effective and safe treatment option for LS, based on the significant improvements seen in investigator evaluations, patient-reported outcomes and skin imaging findings.

引用

页码：136 / 138

页数：3

共 7 条

[1] Cytokine alterations in lichen sclerosus: an immunohistochemical study [J].

Farrell, A. M. ;

Dean, D. ;

Millard, P. R. ;

Charnock, F. M. ;

Wojnarowska, F. .

BRITISH JOURNAL OF DERMATOLOGY, 2006, 155 (05) :931-940

[2] JAK-inhibitors in dermatology - small molecules, big impact? Overview of the mechanism of action, previous study results and potential adverse effects [J].

Klein, Benjamin ;

Treudler, Regina ;

Simon, Jan C. .

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2022, 20 (01) :19-24

[3] British Association of Dermatologists guidelines for the management of lichen sclerosus, 2018 [J].

Lewis, F. M. ;

Tatnall, F. M. ;

Velangi, S. S. ;

Bunker, C. B. ;

Kumar, A. ;

Brackenbury, F. ;

Mustapa, M. F. Mohd ;

Exton, L. S. .

BRITISH JOURNAL OF DERMATOLOGY, 2018, 178 (04) :839-853

[4] Platelet-rich plasma for male genital lichen sclerosus resistant to conventional therapy: First prospective study [J].

Navarrete, Jorge ;

Echarte, Lourdes ;

Sujanov, Alexandra ;

Guillones, Astrid ;

Vola, Magdalena ;

Bunker, Christopher Barry ;

Agorio, Caroline ;

Tourino, Cristina .

DERMATOLOGIC THERAPY, 2020, 33 (06)

[5] A therapeutic approach for female, relapsing genital lichen sclerosus: a single-center study [J].

Patsatsi, Aikaterini ;

Kyriakou, Aikaterini ;

Vavilis, Dimitrios ;

Mantas, Athanasios ;

Patsialas, Christos ;

Sotiriadis, Dimitrios .

JOURNAL OF DERMATOLOGICAL TREATMENT, 2013, 24 (05) :336-339

[6] An Autoimmune Phenotype in Vulvar Lichen Sclerosus and Lichen Planus: A Th1 Response and High Levels of MicroRNA-155 [J].

Terlou, Annelinde ;

Santegoets, Lindy A. M. ;

van der Meijden, Willem I. ;

Heijmans-Antonissen, Claudia ;

Swagemakers, Sigrid M. A. ;

van der Spek, Peter J. ;

Ewing, Patricia C. ;

van Beurden, Marc ;

Helmerhorst, Theo J. M. ;

Blok, Leen J. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2012, 132 (03) :658-666

[7] Lichen Sclerosus: An autoimmunopathogenic and genomic enigma with emerging genetic and immune targets [J].

Tran, Davis A. ;

Tan, Xiaohui ;

Macri, Charles J. ;

Goldstein, Andrew T. ;

Fu, Sidney W. .

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2019, 15 (07) :1429-1439

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