DNA hypomethylation and upregulated LINC00518 acts as a promoter and biomarker in head and neck squamous cell carcinoma

被引：2

作者：

Wang, Xueqin ^{[1
]}

Shen, Jinquan ^{[2
]}

Wang, Laifa ^{[1
]}

Deng, Ling ^{[1
]}

Bo, Hao ^{[3
]}

Luo, Yanwei ^{[4
]}

Cui, Yanhui ^{[2
]}

机构：

[1] Changsha Med Univ, Ctr Neurosci & Behav, Academician Workstat, Changsha 410219, Peoples R China

[2] Cent South Univ, Sch Basic Med Sci, Dept Anat & Neurobiol, Changsha 410013, Peoples R China

[3] Reprod & Genet Hosp CITIC Xiangya, Clin Res Ctr Reprod & Genet Hunan Prov, Changsha 410000, Peoples R China

[4] Cent South Univ, Xiangya Hosp 3, Dept Blood Transfus, Changsha 410013, Peoples R China

来源：

EPIGENOMICS | 2023年 / 15卷 / 05期

关键词：

gene-based therapy; head and neck squamous cell carcinoma (HNSCC); HMGA2; hypomethylation; lncRNAs; tumor immunity; LONG NONCODING RNAS; CANCER; PROLIFERATION; METASTASIS;

D O I：

10.2217/epi-2023-0053

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: LINC00518 acts as an oncogene in several cancers, but its function in head and neck squamous cell carcinoma (HNSCC) remains unclear. Materials & methods: The expression and methylation status of LINC00518 were analyzed by reviewing public databases. The ceRNA network and the relationship with tumor immunity of LINC00518 were analyzed using online tools and in vitro studies. Results: Upregulated LINC00518 was associated with poor clinicopathological characteristics of HNSCC. Silencing LINC00518 significantly inhibited the migration of HNSCC cells. LINC00518 might positively regulate HMGA2 via the ceRNA mechanism. Additionally, LINC00518 was negatively correlated with various immune cells and immunotherapy markers. Moreover, the upregulation of LINC00518 in HNSCC may be due to DNA hypomethylation. Conclusion: LINC00518 may be a potential biomarker and therapeutic target for HNSCC.

引用

页码：293 / 306

页数：14

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