Aldehyde Olefination with Arylboroxines Enabled by Binary Rhodium Catalysis

被引：5

作者：

Hu, Fangdong ^{[1
]}

Xia, Ying ^{[2
,3
,4
]}

Zhang, Zihao ^{[1
,2
,3
,4
]}

Jia, Jie ^{[2
,3
,4
]}

机构：

[1] Linyi Univ, Sch Chemistr y & Chem Engn, Linyi 276000, Peoples R China

[2] Sichuan Univ, West China Sch Publ Hlth, Chengdu 610041, Sichuan, Peoples R China

[3] Sichuan Univ, West China Hosp 4, Chengdu 610041, Sichuan, Peoples R China

[4] Sichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 18期

关键词：

ENANTIOSELECTIVE TOTAL-SYNTHESIS; ORGANOBORON REAGENTS; ARYL; KETONES; MECHANISM;

D O I：

10.1021/acs.orglett.3c00916

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rhodium-catalyzed olefination of aliphatic alde-hydes with arylboroxines is described. The simple rhodium(I) complex [Rh(cod)OH]2 without any external ligands or additives is able to catalyze the reaction in air and neutral conditions, allowing the construction of aryl olefins in an efficient manner with a good functional group tolerance. The mechanistic investigation illustrates that the binary rhodium catalysis is the key for the transformation, which involves a Rh(I)-catalyzed 1,2-addition and a Rh(III)-catalyzed elimination.

引用

页码：3228 / 3233

页数：6

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