Comprehending Adult Zebrafish (Danio rerio) as a model organism for Alzheimer's disease

The classical hallmarks of Alzheimer's disease are the senile plaques of Amyloid ss and neurofibrillary tangles of hyperphosphorylated tau. The pathophysiology of AD includes changes in the levels of neurotransmitters such as GABA, serotonin, glutamate, acetylcholine etc. and neuroinflammation corresponding to microglial activation, eventually leading to neuronal cell death. Mitochondrial dysfunctions in terms of impaired cellular energy, defective axonal transport, mitochondrial membrane permeabilization and calcium dysregulation, are linked to the pathogenesis of AD. The adult Zebrafish can be utilised as an effective model to study AD due to its behavioural patterns, easy manipulation and sensitivity to neurotropic drugs. This facilitates the establishment of behavioural, neuropharmacological or transgenic models of AD in Zebrafish. Combining various methods of AD induction in adult Zebrafish may render a holistic model expressing the characteristic features to study the pathogenesis and utilise the in vivo model for drug screening.