Stereotactic body radiation therapy for spinal metastases: A new standard of care

被引：7

作者：

Sacino, Amanda N. ^{[2
]}

Chen, Hanbo ^{[3
]}

Sahgal, Arjun ^{[3
]}

Bettegowda, Chetan ^{[2
]}

Rhines, Laurence D. ^{[4
]}

Maralani, Pejman ^{[5
]}

Redmond, Kristin J. ^{[1
,6
]}

机构：

[1] Johns Hopkins Univ, Dept Radiat & Mol Oncol, 401 North Broadway,Suite 1440, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Dept Neurosurg, Baltimore, MD USA

[3] Univ Toronto, Odette Canc Ctr, Sunnybrook Hlth Sci Ctr, Dept Radiat Oncol, Toronto, ON, Canada

[4] MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX USA

[5] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Med Imaging, Toronto, ON, Canada

[6] Johns Hopkins Univ, Dept Radiat Oncol & Mol Radiat Sci, Baltimore, MD USA

来源：

NEURO-ONCOLOGY | 2024年 / 26卷

关键词：

dose selection; local control; SBRT; spinal metastases; target delineation; VERTEBRAL COMPRESSION FRACTURE; EXTERNAL-BEAM RADIOTHERAPY; CIRCULATING-TUMOR DNA; CORD COMPRESSION; INTERNATIONAL CONSENSUS; RANDOMIZED-TRIAL; PHASE-III; 24; GY; RADIOSURGERY; INSTABILITY;

D O I：

10.1093/neuonc/noad225

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Advancements in systemic therapies for patients with metastatic cancer have improved overall survival and, hence, the number of patients living with spinal metastases. As a result, the need for more versatile and personalized treatments for spinal metastases to optimize long-term pain and local control has become increasingly important. Stereotactic body radiation therapy (SBRT) has been developed to meet this need by providing precise and conformal delivery of ablative high-dose-per-fraction radiation in few fractions while minimizing risk of toxicity. Additionally, advances in minimally invasive surgical techniques have also greatly improved care for patients with epidural disease and/or unstable spines, which may then be combined with SBRT for durable local control. In this review, we highlight the indications and controversies of SBRT along with new surgical techniques for the treatment of spinal metastases.

引用

页码：S76 / S87

页数：12

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