Adapted problem adaptation therapy for depression in mild to moderate Alzheimer's disease dementia: A randomized controlled trial

被引：5

作者：

Howard, Robert ^{[1
]}

Cort, Elizabeth ^{[1
]}

Rawlinson, Charlotte ^{[1
]}

Wiegand, Martin ^{[2
]}

Downey, Anne ^{[2
]}

Lawrence, Vanessa ^{[3
]}

Banerjee, Sube ^{[4
]}

Bentham, Peter ^{[5
]}

Fox, Chris ^{[6
]}

Harwood, Rowan ^{[7
]}

Hunter, Rachel ^{[2
]}

Livingston, Gill ^{[1
]}

Moniz-Cook, Esme ^{[8
]}

Panca, Monica ^{[2
]}

Raczek, Malgorzata ^{[9
]}

Ivenso, Chineze ^{[10
]}

Russell, Gregor ^{[11
]}

Thomas, Alan ^{[12
]}

Wilkinson, Philip ^{[13
]}

Freemantle, Nicholas ^{[14
]}

Gould, Rebecca ^{[1
]}

机构：

[1] UCL, Div Psychiat, London, England

[2] UCL, Priment Clin Trials Unit, London, England

[3] Kings Coll London, David Goldberg Ctr H1 01, London, England

[4] Univ Plymouth, Plymouth, Devon, England

[5] Birmingham & Solihull NHS Trust, Birmingham, England

[6] Univ East Anglia, Norwich, Norfolk, England

[7] Univ Nottingham, Queens Med Ctr, Nottingham, England

[8] Univ Hull, Kingston Upon Hull, England

[9] Brighton & Sussex Sch Med, Brighton, E Sussex, England

[10] Aneurin Bevan NHS Trust, St Cadocs Hosp, Newport, Wales

[11] Bradford Dist Care Fdn Trust, Bradford, England

[12] Univ Newcastle, Campus Ageing & Vital, Newcastle Upon Tyne, England

[13] Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford, England

[14] UCL, Comprehens Clin Trials Unit, London, England

来源：

ALZHEIMERS & DEMENTIA | 2024年 / 20卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; clinical trial; depression; mood; problem adaptation therapy; psychological; psychotherapy; MINI-MENTAL-STATE; ANXIETY; PEOPLE; SCALE;

D O I：

10.1002/alz.13766

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: Trials of effectiveness of treatment options for depression in dementia are an important priority. METHODS: Randomized controlled trial to assess adapted Problem Adaptation Therapy (PATH) for depression in mild/moderate dementia caused by Alzheimer's disease. RESULTS: Three hundred thirty-six participants with mild or moderate dementia, >7 on Cornell Scale for Depression in Dementia (CSDD), randomized to adapted PATH or treatment as usual. Mean age 77.0 years, 39.0% males, mean Mini-Mental State Examination 21.6, mean CSDD 12.9. For primary outcome (CSDD at 6 months), no statistically significant benefit with adapted PATH on the CSDD (6 months: -0.58; 95% CI -1.71 to 0.54). The CSDD at 3 months showed a small benefit with adapted PATH (-1.38; 95% CI -2.54 to -0.21) as did the EQ-5D (-4.97; 95% CI -9.46 to -0.48). DISCUSSION: An eight-session course of adapted PATH plus two booster sessions administered within NHS dementia services was not effective treatment for depression in people with mild and moderate dementia. Future studies should examine the effect of more intensive and longer-term therapy.

引用

页码：2990 / 2999

页数：10