Programmed death-ligand 1 expression in tumor cells and tumor-infiltrating lymphocytes are associated with depth of tumor invasion in penile cancer

被引：2

作者：

Sangkhamanon, Sakkarn ^{[1
]}

Kotano, Natcha ^{[1
]}

Sirithanaphol, Wichien ^{[2
]}

Rompsaithong, Ukrit ^{[2
]}

Kiatsopit, Pakorn ^{[2
]}

Sookprasert, Aumkhae ^{[3
]}

Wirasorn, Kosin ^{[3
]}

Twinprai, Prin ^{[4
]}

Watcharenwong, Piyakarn ^{[3
]}

Chindaprasirt, Jarin ^{[3
,5
]}

机构：

[1] Khon Kaen Univ, Fac Med, Dept Pathol, Khon Kaen 40002, Thailand

[2] Khon Kaen Univ, Fac Med, Dept Surg, Div Urol Surg, Khon Kaen 40002, Thailand

[3] Khon Kaen Univ, Fac Med, Dept Internal Med, Div Med Oncol, Khon Kaen 40002, Thailand

[4] Khon Kaen Univ, Fac Med, Dept Radiol, Khon Kaen 40002, Thailand

[5] Khon Kaen Univ, Fac Med, Dept Internal Med, Div Med Oncol, 123 Mitraparp Rd, Khon Kaen 40002, Thailand

来源：

BIOMEDICAL REPORTS | 2023年 / 19卷 / 01期

关键词：

penile cancer; PD-L1; programmed death-ligand 1; squamous cell carcinoma of penis; PD-L1; EXPRESSION;

D O I：

10.3892/br.2023.1627

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The present study aimed to demonstrate the proportion of the programmed death-ligand 1 (PD-L1) expression in penile cancer patients and the association with clinicopathological parameters. Formalin-fixed paraffin-embedded specimens were obtained from 43 patients with primary penile squamous cell carcinoma treated at Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, between 2008 and 2018. PD-L1 expression was evaluated by the immunohistochemistry using an SP263 monoclonal antibody. PD-L1 positivity was defined as >25% tumor cell staining or >25% tumor-associated immune cell staining. The correlation between PD-L1 expression and clinicopathological parameters was analyzed. A total of eight of 43 patients (18.6%) were identified as positive for PD-L1 expression in tumor cells and tumor-infiltrating lymphocytes. In the PD-L1 positive group, there was a significant association with pathological T stage (P=0.014) with a higher percentage of PD-L1 positive tumors in T1 stage compared with T2-T4 stage. In this cohort, there was a trend towards longer survival in patients with positive PD-L1 expression (5-year OS: 75% vs. 61.2%, P=0.19). Lymph node involvement and the location of tumor at the shaft of penis were two independent prognostic factors for survival. In conclusion, the PD-L1 expression was detected in 18% of penile cancer patients and high expression of PD-L1 was associated with the early T stage.

引用

页数：8