Synthesis of ?-Ketonitriles via N-Heterocyclic-Carbene-Catalyzed Radical Coupling of Aldehydes and Azobis(isobutyronitrile)

被引：13

作者：

Wang, Jiao-Mei ^{[1
]}

Chen, Teng ^{[1
]}

Yao, Chang-Sheng ^{[2
]}

Zhang, Kai ^{[2
]}

机构：

[1] Xuzhou Univ Technol, Sch Mat & Chem Engn, Xuzhou 221018, Peoples R China

[2] Jiangsu Normal Univ, Sch Chemistr y & Mat Sci, Jiangsu Key Lab Green Synthet Chem Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 18期

基金：

中国国家自然科学基金;

关键词：

CARBONYLATIVE ALPHA-ARYLATION; BETA-KETONITRILES; ELECTROPHILIC CYANATION; ONE-POT; ACYLATIONS; AIBN;

D O I：

10.1021/acs.orglett.3c01168

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, an NHC (N-heterocyclic carbene)-catalyzed radical coupling reaction between aldehydes and azobis(isobutyronitrile) (AIBN) has been developed. This method provides an efficient and convenient approach for the synthesis of fi-ketonitriles containing a quaternary carbon center (31 examples, up to >99% yield) utilizing commercially available substrates. This protocol features broad substrate scope, good functional group tolerance, and high efficiency under metal-free and mild reaction conditions.

引用

页码：3325 / 3329

页数：5

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