Copper-catalyzed aerobic oxidation of primary alcohols to carboxylic acids

被引：10

作者：

Yu, Yibo ^{[1
]}

Zhai, Di ^{[1
]}

Zhou, Zhengnan ^{[1
]}

Jiang, Sheng ^{[1
]}

Qian, Hui ^{[1
]}

Ma, Shengming ^{[1
,2
]}

机构：

[1] Fudan Univ, Res Ctr Mol Recognit & Synth, Dept Chem, 220 Handan Lu, Shanghai 200433, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Lingling Lu, Shanghai 200032, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 35期

基金：

中国国家自然科学基金;

关键词：

544.1 Copper - 802.2 Chemical Reactions - 804.1 Organic Compounds;

D O I：

10.1039/d3cc00963g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here, the first copper-catalyzed aerobic oxidation of primary alcohols to carboxylic acids with TEMPO and KHSO4 as the co-catalysts has been developed. The reaction exhibits excellent substrate scope and functional group compatibility under mild conditions. Even the very sensitive chiral alcohols, chiral amino alcohols, and alcohol-containing steroid skeletons may be oxidized to afford the corresponding carboxylic acids or lactones without racemization.

引用

页码：5281 / 5284

页数：4

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