Synthetic Approaches to the New Drugs Approved During 2022

被引：11

作者：

France, Scott P. ^{[1
]}

Lindsey, Erick A. ^{[2
]}

McInturff, Emma L. ^{[3
]}

Berritt, Simon ^{[3
]}

Carney, Daniel W. ^{[2
]}

DeForest, Jacob C. ^{[4
]}

Fink, Sarah J. ^{[5
]}

Flick, Andrew C. ^{[2
]}

Gibson, Tony S. ^{[2
]}

Gray, Kaitlyn ^{[3
]}

Johnson, Amber M. ^{[3
]}

Leverett, Carolyn A. ^{[3
]}

Liu, Yiyang ^{[3
]}

Mahapatra, Subham ^{[3
]}

Watson, Rebecca B. ^{[4
]}

机构：

[1] Merck & Co Inc, Proc Res & Dev, Rahway, NJ 07065 USA

[2] Takeda San Diego, San Diego, CA 92121 USA

[3] Pfizer Inc, Groton, CT 06340 USA

[4] Pfizer Inc, San Diego, CA 92130 USA

[5] Crosswalk Therapeut, Cambridge, MA 02139 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2024年 / 67卷 / 06期

关键词：

ORALLY BIOAVAILABLE INHIBITOR; CELL LUNG-CANCER; 1ST APPROVAL; DOUBLE-BLIND; PHASE-II; IN-VITRO; POTENT; IDENTIFICATION; SAFETY; PHARMACOKINETICS;

D O I：

10.1021/acs.jmedchem.3c02374

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In 2022, 23 new small molecule chemical entities were approved as drugs by the United States FDA, European Union EMA, Japan PMDA, and China NMPA. This review describes the synthetic approach demonstrated on largest scale for each new drug based on patent or primary literature. The synthetic routes highlight practical methods to construct molecules, sometimes on the manufacturing scale, to access the new drugs. Ten additional drugs approved in 2021 and one approved in 2020 are included that were not covered in the previous year's review.

引用

页码：4376 / 4418

页数：43

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