Cancer-Associated Fibroblasts: Heterogeneity and Bimodality in Oncogenesis

被引：1

作者：

Lunina, N. A. ^{[1
]}

Safina, D. R. ^{[1
]}

Kostrov, S. V. ^{[1
]}

机构：

[1] Natl Res Ctr Kurchatov Inst, Moscow 123182, Russia

来源：

MOLECULAR BIOLOGY | 2023年 / 57卷 / 05期

关键词：

cancer-associated fibroblasts; heterogeneity; markers; oncogenesis; metastasis; tumor stroma; tumor microenvironment; CARCINOMA-ASSOCIATED FIBROBLASTS; MESENCHYMAL STEM-CELLS; PROMOTES TUMOR-GROWTH; PHASE-II TRIAL; BREAST-CANCER; STROMAL MYOFIBROBLASTS; ACTIVATION PROTEIN; INITIATING CELLS; POOR-PROGNOSIS; LUNG-CANCER;

D O I：

10.1134/S0026893323050096

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer-associated fibroblasts (CAFs) often form a major component of the tumor microenvironment (TMA), providing conditions for cancer cells to thrive. CAFs may contribute to tumor growth, invasion, metastasis, and resistance to therapy. However, clinical trials of treatment strategies targeting CAFs have largely failed. Moreover, there is evidence that CAFs are capable of inhibiting tumor development. The review considers the current data on the functional heterogeneity of CAFs and their bimodality in tumor development and progression. Understanding the tumor-promoting and tumor-inhibiting activities of CAFs can help to develop new diagnostic and therapeutic approaches.

引用

页码：765 / 792

页数：28

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