The Potential of Mur Enzymes as Targets for Antimicrobial Drug Discovery

被引：4

作者：

Kumar, Dharmendra ^{[1
]}

Sarkar, Nandan ^{[2
]}

Roy, Kuldeep K. ^{[3
]}

Bisht, Dheeraj ^{[4
]}

Kumar, Deepak ^{[5
]}

Mandal, Bitasta ^{[2
]}

Rajagopal, Mogana ^{[6
]}

Dey, Yadu Nandan ^{[7
]}

机构：

[1] Gopal Narayan Singh Univ, Narayan Inst Pharm, Jamuhar 821305, Bihar, India

[2] Adamas Univ, Sch Med Sci, Dept Pharmaceut Technol, Kolkata 700126, India

[3] Sch Hlth Sci & Technol, Dept Pharmaceut Sci, UPES, Dehra Dun 248007, India

[4] Kumaun Univ, Dept Pharmaceut Sci, Bhimtal Campus, Naini Tal 263136, Uttarakhand, India

[5] Shoolini Univ, Sch Pharmaceut Sci, Dept Pharmaceut Chem, Solan 173229, Himachal Prades, India

[6] UCSI Univ, Fac Pharmaceut Sci, Kuala Lumpur 56000, Malaysia

[7] Dr B C Roy Coll Pharm & Allied Hlth Sci, Dept Pharmacol, Durgapur 713206, W Bengal, India

来源：

CURRENT DRUG TARGETS | 2023年 / 24卷 / 08期

关键词：

Antibacterial agents; inhibitor; ligase; mur enzymes; peptidoglycan; antimicrobial; UDP-N-ACETYLGLUCOSAMINE; ALANINE LIGASE MURC; D-GLUTAMIC ACID; MESO-DIAMINOPIMELATE LIGASE; ALANYL-D-GLUTAMATE; X-RAY-ANALYSIS; ESCHERICHIA-COLI; PEPTIDOGLYCAN BIOSYNTHESIS; ADDING ENZYME; CRYSTAL-STRUCTURES;

D O I：

10.2174/1389450124666230608150759

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The extensive development in the strains of resistant bacteria is a potential hazard to public health worldwide. This necessitates the development of newer agents with the antibacterial property having new mechanisms of action. Mur enzymes catalyze the steps related to the biosynthesis of peptidoglycan, which constitutes a major part of the cell wall in bacteria. Peptidoglycan increases the stiffness of the cell wall, helping it to survive in unfavorable conditions. Therefore, the inhibition of Mur enzymes may lead to novel antibacterial agents that may help in controlling or overcoming bacterial resistance. Mur enzymes are classified into MurA, MurB, MurC, MurD, MurE, and MurF. Until-date, multiple inhibitors are reported for each class of the Mur enzymes. In this review, we have summarized the development of Mur enzyme inhibitors as antibacterial agents in the last few decades.

引用

页码：627 / 647

页数：21

共 129 条

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