Rapid kidney function decline and increased risk of heart failure in patients with type 2 diabetes: findings from the ACCORD cohort Rapid kidney function decline and heart failure in T2D

被引:3
作者
Bueno Junior, Carlos Roberto [1 ,2 ,3 ]
Bano, Arjola [1 ,2 ,4 ,5 ]
Tang, Yaling [1 ,2 ]
Sun, Xiuqin [1 ,2 ,6 ]
Abate, Alex [1 ]
Hall, Elizabeth [1 ,2 ]
Mitri, Joanna [1 ,2 ]
Morieri, Mario Luca [7 ]
Shah, Hetal [1 ,2 ]
Doria, Alessandro [1 ,2 ,8 ]
机构
[1] Joslin Diabet Ctr, Res Div, Boston, MA 02215 USA
[2] Harvard Med Sch, Dept Med, Boston, MA 02115 USA
[3] Univ Sao Paulo, Coll Nursing Ribeirao Preto, Sch Phys Educ & Sport, Med Sch, Ribeirao Preto, SP, Brazil
[4] Univ Bern, Inst Social & Prevent Med ISPM, Bern, Switzerland
[5] Univ Bern, Bern Univ Hosp, Dept Cardiol, Bern, Switzerland
[6] Peking Univ, Dept Endocrine & Metab, Shuang Hosp, Beijing, Peoples R China
[7] Univ Padua, Univ Hosp Padova, Dept Med, Metab Dis Unit, Padua, Italy
[8] Joslin Diabet Ctr, Res Div, One Joslin Pl, Boston, MA 02215 USA
基金
美国国家卫生研究院; 巴西圣保罗研究基金会;
关键词
Heart failure; Diabetic kidney disease; Type; 2; diabetes; Glomerular filtration rate; Albuminuria; CARDIAC AUTONOMIC NEUROPATHY; PROGRESSIVE RENAL DECLINE; CARDIOVASCULAR EVENTS; HYPERTENSION; NEPHROPATHY; THERAPY; CURVE;
D O I
10.1186/s12933-023-01869-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Impaired kidney function and albuminuria are associated with increased risk of heart failure (HF) in patients with type 2 diabetes (T2D). We investigated whether rapid kidney function decline over time is an additional determinant of increased HF risk in patients with T2D, independent of baseline kidney function, albuminuria, and other HF predictors. Methods Included in the study were 7,539 participants in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study with baseline urinary albumin-to-creatinine ratio (UACR) data, who had completed 4 years of follow-up and had >= 3 eGFR measurements during that period (median eGFR/year = 1.9, IQR 1.7-3.2). The association between rapid kidney function decline (eGFR loss >= 5 ml/min/1.73 m(2)/year) and odds of HF hospitalization or HF death during the first 4 years of follow-up was estimated by logistic regression. The improvement in risk discrimination provided by adding rapid kidney function decline to other HF risk factors was evaluated as the increment in the area under the Receiving Operating Characteristics curve (ROC AUC) and integrated discrimination improvement (IDI). Results Over 4 years of follow-up, 1,573 participants (20.9%) experienced rapid kidney function decline and 255 (3.4%) experienced a HF event. Rapid kidney function decline was associated with a similar to 3.2-fold increase in HF odds (3.23, 95% CI, 2.51-4.16, p < 0.0001), independent of baseline CVD history. This estimate was not attenuated by adjustment for potential confounders, including eGFR and UACR at baseline as well as at censoring (3.74; 95% CI 2.63-5.31). Adding rapid kidney function decline during follow-up to other clinical predictors (WATCH-DM score, eGFR, and UACR at study entry and end of follow-up) improved HF risk classification (ROC AUC = + 0.02, p = 0.027; relative IDI = + 38%, p < 0.0001). Conclusions In patients with T2D, rapid kidney function decline is associated with a marked increase in HF risk, independent of starting kidney function and/or albuminuria. These findings highlight the importance of serial eGFR measurements over time to improve HF risk estimation in T2D.
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页数:12
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