Pathological Characteristics of Domestic Pigs Orally Infected with the Virus Strain Causing the First Reported African Swine Fever Outbreaks in Vietnam

被引：4
作者：
Nguyen, Thi Thu Huyen [1 ,2 ]
Nguyen, Van Tam [3 ]
Le, Phuong Nam [3 ]
Mai, Nguyen Tuan Anh [3 ]
Dong, Van Hieu [1 ]
Bui, Tran Anh Dao [1 ]
Nguyen, Thi Lan [1 ]
Ambagala, Aruna [4 ]
Le, Van Phan [1 ,3 ]
机构：
[1] Vietnam Natl Univ Agr, Coll Vet Med, Hanoi 100000, Vietnam
[2] Bac Giang Agr & Forestry Univ, Fac Anim Sci & Vet Med, Bac Giang 230000, Vietnam
[3] Inst Vet Sci & Technol IVST, Hanoi 100000, Vietnam
[4] Canadian Food Inspect Agcy, Natl Ctr Foreign Anim Dis, Winnipeg, MB R3E 3M4, Canada
来源：
PATHOGENS | 2023年 / 12卷 / 03期
关键词：
ASFV; clinical signs; gross findings; orally experimental infection; pathology;
D O I：
10.3390/pathogens12030393
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
African swine fever (ASF) is currently Vietnam's most economically significant swine disease. The first ASF outbreak in Vietnam was reported in February 2019. In this study, VNUA/HY/ASF1 strain isolated from the first ASF outbreak was used to infect 10 eight-week-old pigs orally with 10(3) HAD(50) per animal. The pigs were observed daily for clinical signs, and whole blood samples were collected from each animal for viremia detection. Dead pigs were subjected to full post-mortem analyses. All 10 pigs displayed acute or subacute clinical signs and succumbed to the infection between 10 to 27 (19.8 +/- 4.66) days post-inoculation (dpi). The onset of clinical signs started around 4-14 dpi. Viremia was observed in pigs from 6-16 dpi (11.2 +/- 3.55). Enlarged, hyperemic, and hemorrhagic lymph nodes, enlarged spleen, pneumonia, and hydropericardium were observed at post-mortem examinations.
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  • [1] Clinical and Pathological Study of the First Outbreak Cases of African Swine Fever in Vietnam, 2019
    Bui Thi To Nga
    Bui Tran Anh Dao
    Lan Nguyen Thi
    Osaki, Makoto
    Kawashima, Kenji
    Song, Daesub
    Salguero, Francisco J.
    Van Phan Le
    [J]. FRONTIERS IN VETERINARY SCIENCE, 2020, 7
  • [2] Comparison of the Virulence of Korean African Swine Fever Isolates from Pig Farms during 2019-2021
    Cho, Ki-Hyun
    Hong, Seong-Keun
    Jang, Min-Kyung
    Ryu, Ji-Hyoung
    Kim, Hyun-Jeong
    Lee, Yu-Ran
    Roh, In-Soon
    Sohn, Hyun-Joo
    Kang, Hae-Eun
    Park, Jee-Yong
    [J]. VIRUSES-BASEL, 2022, 14 (11):
  • [3] Survival of viral pathogens in animal feed ingredients under transboundary shipping models
    Dee, Scott A.
    Bauermann, Fernando V.
    Niederwerder, Megan C.
    Singrey, Aaron
    Clement, Travis
    de Lima, Marcelo
    Long, Craig
    Patterson, Gilbert
    Sheahan, Maureen A.
    Stoian, Ana M. M.
    Petrovan, Vlad
    Jones, Cassandra K.
    De Jong, Jon
    Ji, Ju
    Spronk, Gordon D.
    Minion, Luke
    Christopher-Hennings, Jane
    Zimmerman, Jeff J.
    Rowland, Raymond R. R.
    Nelson, Eric
    Sundberg, Paul
    Diel, Diego G.
    [J]. PLOS ONE, 2018, 13 (03):
  • [4] African swine fever virus replication and genomics
    Dixon, Linda K.
    Chapman, David A. G.
    Netherton, Christopher L.
    Upton, Chris
    [J]. VIRUS RESEARCH, 2013, 173 (01) : 3 - 14
  • [5] African Swine Fever Virus: A Review
    Galindo, Inmaculada
    Alonso, Covadonga
    [J]. VIRUSES-BASEL, 2017, 9 (05):
  • [6] Standardization of pathological investigations in the framework of experimental ASFV infections
    Galindo-Cardiel, Ivan
    Ballester, Maria
    Solanes, David
    Nofrarias, Miquel
    Lopez-Soria, Sergio
    Argilaguet, Jordi M.
    Lacasta, Anna
    Accensi, Francesc
    Rodriguez, Fernando
    Segales, Joaquim
    [J]. VIRUS RESEARCH, 2013, 173 (01) : 180 - 190
  • [7] Genetic Variation among African Swine Fever Genotype II Viruses, Eastern and Central Europe
    Gallardo, Carmina
    Fernandez-Pinero, Jovita
    Pelayo, Virginia
    Gazaev, Ismail
    Markowska-Daniel, Iwona
    Pridotkas, Gediminas
    Nieto, Raquel
    Fernandez-Pacheco, Paloma
    Bokhan, Svetlana
    Nevolko, Oleg
    Drozhzhe, Zhanna
    Perez, Covadonga
    Soler, Alejandro
    Kolvasov, Denis
    Arias, Marisa
    [J]. EMERGING INFECTIOUS DISEASES, 2014, 20 (09) : 1544 - 1547
  • [8] Evaluation of oral fluid as an aggregate sample for early detection of African swine fever virus using four independent pen-based experimental studies
    Goonewardene, Kalhari B.
    Chung, Chungwon J.
    Goolia, Melissa
    Blakemore, Leslie
    Fabian, Andrew
    Mohamed, Fawzi
    Nfon, Charles
    Clavijo, Alfonso
    Dodd, Kimberly A.
    Ambagala, Aruna
    [J]. TRANSBOUNDARY AND EMERGING DISEASES, 2021, 68 (05) : 2867 - 2877
  • [9] Dynamics of African swine fever virus shedding and excretion in domestic pigs infected by intramuscular inoculation and contact transmission
    Guinat, Claire
    Reis, Ana Luisa
    Netherton, Christopher L.
    Goatley, Lynnette
    Pfeiffer, Dirk U.
    Dixon, Linda
    [J]. VETERINARY RESEARCH, 2014, 45
  • [10] Pathogenesis of highly virulent African swine fever virus in domestic pigs exposed via intraoropharyngeal, intranasopharyngeal, and intramuscular inoculation, and by direct contact with infected pigs
    Howey, Erin B.
    O'Donnell, Vivian
    Ferreira, Helena C. de Carvalho
    Borca, Manuel V.
    Arzt, Jonathan
    [J]. VIRUS RESEARCH, 2013, 178 (02) : 328 - 339
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