Recent Developments in Glioblastoma Therapy: Oncolytic Viruses and Emerging Future Strategies

被引：51
作者：
Hamad, Azzam [1 ]
Yusubalieva, Gaukhar M. [2 ,3 ]
Baklaushev, Vladimir P. [2 ,3 ]
Chumakov, Peter M. [1 ]
Lipatova, Anastasiya V. [1 ]
机构：
[1] Russian Acad Sci, Engelhardt Inst Mol Biol, Ctr Precis Genome Editing & Genet Technol Biomed, Moscow 119991, Russia
[2] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia
[3] Fed Med & Biol Agcy Russia, Fed Res & Clin Ctr Specialized Med Care & Med Tech, Moscow 115682, Russia
来源：
VIRUSES-BASEL | 2023年 / 15卷 / 02期
基金：
俄罗斯科学基金会;
关键词：
glioblastoma; immunotherapy; CAR T; oncolytic viruses; poliovirus; viral vector; recombinant strain; cancer immunotherapy; nanoparticles; proteomics; HERPES-SIMPLEX-VIRUS; MEDIATED CYTOTOXIC IMMUNOTHERAPY; SIGNIFICANT ANTITUMOR-ACTIVITY; NEWLY-DIAGNOSED GLIOBLASTOMA; RECURRENT MALIGNANT GLIOMAS; PHASE-II MULTICENTER; MEASLES-VIRUS; DOSE-ESCALATION; MYXOMA VIRUS; GENE-THERAPY;
D O I：
10.3390/v15020547
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Glioblastoma is the most aggressive form of malignant brain tumor. Standard treatment protocols and traditional immunotherapy are poorly effective as they do not significantly increase the long-term survival of glioblastoma patients. Oncolytic viruses (OVs) may be an effective alternative approach. Combining OVs with some modern treatment options may also provide significant benefits for glioblastoma patients. Here we review virotherapy for glioblastomas and describe several OVs and their combination with other therapies. The personalized use of OVs and their combination with other treatment options would become a significant area of research aiming to develop the most effective treatment regimens for glioblastomas.
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页数：25
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