Vanadyl Naphthalocyanine-Doped Polymer Dots for Near-Infrared Light-Induced Nitric Oxide Release and Bactericidal Effects

被引：5

作者：

Liu, Zuoyue ^{[1
]}

Okada, Yuta ^{[1
]}

Ichinose, Yuma ^{[1
]}

Saitoh, Daisuke ^{[2
]}

Ieda, Naoya ^{[2
]}

Yamasaki, Seiji ^{[1
,3
]}

Nishino, Kunihiko ^{[1
]}

Nakagawa, Hidehiko ^{[2
]}

Fujitsuka, Mamoru ^{[1
,4
]}

Osakada, Yasuko ^{[1
,3
,4
]}

机构：

[1] Osaka Univ, Inst Sci & Ind Res, SANKEN, Osaka, Ibaraki 5670047, Japan

[2] Nagoya City Univ, Grad Sch Pharmaceut Sci, Nagoya, Aichi 4678603, Japan

[3] Osaka Univ, Inst Adv Cocreat Studies, Suita, Osaka 5650871, Japan

[4] Osaka Univ, Inst Open & Transdisciplinary Res Initiat ICS OTR, Innovat Catalysis Sci Div, Suita, Osaka 5650871, Japan

来源：

ACS APPLIED NANO MATERIALS | 2023年 / 6卷 / 02期

关键词：

nitric oxide; photothermal effect; near-infrared light; polymer dots; bactericidal effect; GOLD NANOPARTICLES; NO; DYNAMICS; THERAPY; DESIGN;

D O I：

10.1021/acsanm.2c05566

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The development of efficient antibacterial agents is important for public health. To completely damage bacteria in situ, light has been used as an external stimulus, but the wavelength range of light is limited up to visible light at which the antimicrobial activity is incomplete. Here, we report on our investigation of the bactericidal effect of heat and nitric oxide (NO) generated simultaneously by near-infrared (NIR) light using vanadyl naphthalocyanine-doped polymer dots (P-dots). P-dots co-doped with vanadyl naphthalocyanine and N-nitroso compounds generated heat and released NO upon NIR light irradiation. The amount of NO released was dramatically enhanced owing to the ease of bond dissociation in N- nitroso compounds in the presence of generated heat. The anti-bacterial effect of P-dots on Staphylococcus epidermidis and Pseudomonas aeruginosa was clearly caused by heat and NO, demonstrating the potential use of P-dots as antimicrobial agents.

引用

页码：1487 / 1495

页数：9

共 50 条

[41] The biological lifetime of nitric oxide:: Implications for the perivascular dynamics of NO and O2 [J].

Thomas, DD ;

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Kantrow, SP ;

Lancaster, JR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (01) :355-360

[42] Gut Microbiota, Nitric Oxide, and Microglia as Prerequisites for Neurodegenerative Disorders [J].

Tse, Joyce K. Y. .

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[43] Nitric Oxide Stimulated Programmable Drug Release of Nanosystem for Multidrug Resistance Cancer Therapy [J].

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[44] Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials [J].

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[45] Design of Highly Emissive Polymer Dot Bioconjugates for In Vivo Tumor Targeting [J].

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Jin, Yuhui ;

Burnham, Daniel R. ;

McNeill, Jason D. ;

Olson, James M. ;

Chiu, Daniel T. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (15) :3430-3434

[46] Development of Biomedical Polymer-Silicate Nanocomposites: A Materials Science Perspective [J].

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MATERIALS, 2010, 3 (05) :2986-3005

[47] Low-Temperature Trigger Nitric Oxide Nanogenerators for Enhanced Mild Photothermal Therapy [J].

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[48] Recent Advances in the Development of Highly Luminescent Semiconducting Polymer Dots and Nanoparticles for Biological Imaging and Medicine [J].

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Rong, Yu ;

Kuo, Chun-Ting ;

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Chiu, Daniel T. .

ANALYTICAL CHEMISTRY, 2017, 89 (01) :42-56

[49] Near-Infrared Light-Triggered Nitric-Oxide-Enhanced Photodynamic Therapy and Low-Temperature Photothermal Therapy for Biofilm Elimination [J].

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Chen, Maowen ;

Zhang, Jixi ;

Liu, Peng ;

Cai, Kaiyong .

ACS NANO, 2020, 14 (03) :3546-3562

[50] Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228) [J].

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Ren, SX ;

Li, HL ;

Wang, YX ;

Fu, G ;

Yang, J ;

Qin, ZQ ;

Miao, YG ;

Wang, WY ;

Chen, RS ;

Shen, Y ;

Chen, Z ;

Yuan, ZH ;

Zhao, GP ;

Qu, D ;

Danchin, A ;

Wen, YM .

MOLECULAR MICROBIOLOGY, 2003, 49 (06) :1577-1593

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