Epithelioid glioblastoma diagnosed 70 years after craniofacial radiotherapy

被引：0

作者：

Bugdadi, Abdulgadir ^{[1
,2
]}

Cherif, Mohamed Aziz ^{[3
]}

Loganadane, Gokoulakrichenane ^{[3
]}

Brugieres, Pierre ^{[4
]}

Marniche, Amel ^{[1
]}

Itti, Emmanuel ^{[5
]}

Belkacemi, Yazid ^{[3
]}

Tauziede-Espariat, Arnault ^{[6
]}

Palfi, Stephane ^{[1
]}

Senova, Suhan ^{[1
]}

机构：

[1] Univ Paris Est Creteil, Henri Mondor Univ Hosp, AP HP, Dept Neurosurg,INSERM,Lab Translat Neuropsychiat,I, Creteil, France

[2] Umm Al Qura Univ, Fac Med, Dept Surg, Mecca, Saudi Arabia

[3] Henri Mondor Univ Hosp, Dept Radiotherapy, Creteil, France

[4] Henri Mondor Univ Hosp, Dept Neuroradiol, Creteil, France

[5] Henri Mondor Univ Hosp, Dept Nucl Med, Creteil, France

[6] St Anne Hosp, Dept Neuropathol, Paris, France

来源：

ACTA NEUROCHIRURGICA | 2023年 / 165卷 / 10期

关键词：

Epithelioid glioblastoma; Radiation induced glioma; Latency-period; Brachytherapy; Radiotherapy; CENTRAL-NERVOUS-SYSTEM; IRRADIATION; CHILDHOOD; TUMORS; RISK;

D O I：

10.1007/s00701-023-05637-z

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors report a rare case of most likely radiation-induced glioma (RIG) with epithelioid features and the presence of molecular features consistent with RIG. This occurred 70 years after craniofacial brachytherapy. Such a late development of radiation-induced glioblastoma (RIGBM) and the advanced age of presentation for an epithelioid glioblastoma are both unique in the literature. Despite not receiving the full course of adjuvant chemotherapy after surgery and radiotherapy, the patient displayed no signs of recurrence during a 5-year follow-up. RIGBM should be further studied to reveal potential unique clinical and molecular characteristics, as well as to better predict survival and treatment response.

引用

页码：2769 / 2774

页数：6

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