The NLRP3 inflammasome as a target for sensorineural hearing loss

被引：18
|
作者：
Gregory, Grace E. [1 ,2 ,3 ]
Munro, Kevin J. [4 ,5 ]
Couper, Kevin N. [2 ,3 ]
Pathmanaban, Omar N. [1 ,2 ,3 ,6 ]
Brough, David [1 ,2 ,3 ]
机构：
[1] Univ Manchester, Fac Biol Med & Hlth, Sch Biol Sci, Div Neurosci,Manchester Acad Hlth Sci Ctr, Manchester, England
[2] Univ Manchester, Geoffrey Jefferson Brain Res Ctr, Manchester Acad Hlth Sci Ctr, Northern Care Alliance NHS Grp, Manchester, England
[3] Univ Manchester, Lydia Becker Inst Immunol & Inflammat, Manchester, England
[4] Univ Manchester, Manchester Ctr Audiol & Deafness, Sch Hlth Sci, Manchester, England
[5] Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, England
[6] Salford Royal Hosp NHS Fdn Trust, Manchester Ctr Clin Neurosci, Dept Neurosurg, Salford, England
来源：
CLINICAL IMMUNOLOGY | 2023年 / 249卷
基金：
英国医学研究理事会;
关键词：
Sensorineural hearing loss; Inflammation; Cochlea; NLRP3; inflammasome; Interleukin-1;
D O I：
10.1016/j.clim.2023.109287
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Sensorineural hearing loss is the most common type of hearing loss in adults and occurs due to damage of the inner ear caused by a range of factors including ageing, excessive noise, toxins, and cancer. Auto-inflammatory disease is also a cause of hearing loss and there is evidence that inflammation could contribute to hearing loss in other conditions. Within the inner ear there are resident macrophage cells that respond to insults and whose activation correlates with damage. The NLRP3 inflammasome is a multi-molecular pro-inflammatory protein complex that forms in activated macrophages and may contribute to hearing loss. The aim of this article is to discuss the evidence for the NLRP3 inflammasome and associated cytokines as potential therapeutic targets for sensorineural hearing loss in conditions ranging from auto-inflammatory disease to tumour-induced hearing loss in vestibular schwannoma.
引用
收藏
页数：5
相关论文
共 50 条
  • [21] A Review on the NLRP3 Inflammasome and Stroke
    Tong, Yeqing
    Zhan, Faxian
    Zhang, Yanwei
    Guan, Xu-Hua
    Yin, Xiaoxv
    Geng, Yijie
    Ye, Jian-Jun
    Hou, Shuang-Yi
    Lu, Zuxun
    Wang, Zhihong
    Liu, Jiafa
    8TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICAL ENGINEERING (ICBBE 2014), 2014, : 83 - 88
  • [22] Metabolic Regulation of the NLRP3 Inflammasome
    Ye, Qizhen
    Chen, Sheng
    Wang, Di
    INFECTIOUS MICROBES & DISEASES, 2021, 3 (04): : 183 - 186
  • [23] Targeting the NLRP3 Inflammasome in Glaucoma
    Coyle, Sophie
    Khan, Mohammed Naeem
    Chemaly, Melody
    Callaghan, Breedge
    Doyle, Chelsey
    Willoughby, Colin E.
    Atkinson, Sarah D.
    Gregory-Ksander, Meredith
    McGilligan, Victoria
    BIOMOLECULES, 2021, 11 (08)
  • [24] The Role of NLRP3 Inflammasome in Pericarditis
    Mauro, Adolfo G.
    Bonaventura, Aldo
    Vecchie, Alessandra
    Mezzaroma, Eleonora
    Carbone, Salvatore
    Narayan, Pratyush
    Potere, Nicola
    Cannata, Antonio
    Paolini, John F.
    Bussani, Rossana
    Montecucco, Fabrizio
    Sinagra, Gianfranco
    Van Tassel, Benjamin W.
    Abbate, Antonio
    Toldo, Stefano
    JACC-BASIC TO TRANSLATIONAL SCIENCE, 2021, 6 (02): : 137 - 150
  • [25] Neurodegenerative Disease and the NLRP3 Inflammasome
    Holbrook, Jonathan A.
    Jarosz-Griffiths, Heledd H.
    Caseley, Emily
    Lara-Reyna, Samuel
    Poulter, James A.
    Williams-Gray, Caroline H.
    Peckham, Daniel
    McDermott, Michael F.
    FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [26] Spotlight on the NLRP3 inflammasome pathway
    Groslambert, Marine
    Py, Benedicte F.
    JOURNAL OF INFLAMMATION RESEARCH, 2018, 11 : 359 - 374
  • [27] Role of the NLRP3 inflammasome in cancer
    Moossavi, Maryam
    Parsamanesh, Negin
    Bahrami, Afsane
    Atkin, Stephen L.
    Sahebkar, Amirhossein
    MOLECULAR CANCER, 2018, 17
  • [28] Novel mutation in NLRP3 Exon 7 results in sensorineural hearing loss without chronic inflammation
    L Broderick
    S Cherukumilli Grevich
    C Putnam
    H Hoffman
    Pediatric Rheumatology, 13 (Suppl 1)
  • [29] The role of NLRP3 inflammasome in the pathogenesis of rheumatic disease
    Kong, Ruixue
    Sun, Lulu
    Li, Hua
    Wang, Dashan
    AUTOIMMUNITY, 2022, 55 (01) : 1 - 7
  • [30] NLRP3 inflammasome: The rising star in cardiovascular diseases
    Zheng, Yidan
    Xu, Li
    Dong, Nianguo
    Li, Fei
    FRONTIERS IN CARDIOVASCULAR MEDICINE, 2022, 9
12345