New Strategies for Biocontrol of Bacterial Toxins and Virulence: Focusing on Quorum-Sensing Interference and Biofilm Inhibition

被引：12

作者：

Zhang, Hua ^{[1
,2
]}

Zhang, Zhen ^{[2
]}

Li, Jing ^{[2
]}

Qin, Guangyong ^{[3
]}

机构：

[1] Zhengzhou Univ, Coll Phys, Henan Key Lab Ion Beam Bioengn, Zhengzhou 450000, Peoples R China

[2] Henan Univ Anim Husb & Econ, Sch Food & Biol Engn, Zhengzhou 450046, Peoples R China

[3] Zhengzhou Univ, Sch Agr Sci, Zhengzhou 450000, Peoples R China

来源：

TOXINS | 2023年 / 15卷 / 09期

基金：

中国国家自然科学基金;

关键词：

biocontrol; bacterial toxins; virulence; probiotics; medicinal plants; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; IN-VITRO; SACCHAROMYCES-BOULARDII; LACTOBACILLUS-PLANTARUM; LISTERIA-MONOCYTOGENES; MOLECULAR-MECHANISMS; GENE-EXPRESSION; ESSENTIAL OILS; POTENTIAL USE;

D O I：

10.3390/toxins15090570

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The overuse of antibiotics and the emergence of multiple-antibiotic-resistant pathogens are becoming a serious threat to health security and the economy. Reducing antimicrobial resistance requires replacing antibiotic consumption with more biocontrol strategies to improve the immunity of animals and humans. Probiotics and medicinal plants have been used as alternative treatments or preventative therapies for a variety of diseases caused by bacterial infections. Therefore, we reviewed some of the anti-virulence and bacterial toxin-inhibiting strategies that are currently being developed; this review covers strategies focused on quenching pathogen quorum sensing (QS) systems, the disruption of biofilm formation and bacterial toxin neutralization. It highlights the probable mechanism of action for probiotics and medicinal plants. Although further research is needed before a definitive statement can be made on the efficacy of any of these interventions, the current literature offers new hope and a new tool in the arsenal in the fight against bacterial virulence factors and bacterial toxins.

引用

页数：22