Long-term environmental enrichment is associated with better fornix microstructure in older adults

被引：4

作者：

Klimecki, Olga M. ^{[1
]}

Liebscher, Maxie ^{[1
]}

Gaubert, Malo ^{[1
,2
]}

Hayek, Dayana ^{[3
]}

Zarucha, Alexis ^{[1
]}

Dyrba, Martin ^{[4
]}

Bartels, Claudia ^{[5
]}

Buerger, Katharina ^{[6
,7
]}

Butryn, Michaela ^{[3
]}

Dechent, Peter ^{[8
]}

Dobisch, Laura ^{[3
]}

Ewers, Michael ^{[6
,7
]}

Fliessbach, Klaus ^{[9
,10
]}

Freiesleben, Silka Dawn ^{[11
,12
]}

Glanz, Wenzel ^{[3
]}

Hetzer, Stefan ^{[13
]}

Janowitz, Daniel ^{[7
]}

Kilimann, Ingo ^{[4
,14
]}

Kleineidam, Luca ^{[9
,10
]}

Laske, Christoph ^{[15
,16
]}

Maier, Franziska ^{[17
]}

Munk, Matthias H. ^{[15
,18
]}

Perneczky, Robert ^{[6
,19
,20
,21
]}

Peters, Oliver ^{[11
,12
]}

Priller, Josef ^{[12
,22
,23
,24
,25
]}

Rauchmann, Boris-Stephan ^{[19
]}

Roy, Nina ^{[9
]}

Scheffler, Klaus ^{[26
]}

Schneider, Anja ^{[9
,10
]}

Spruth, Eike Jakob ^{[11
,12
]}

Spottke, Annika ^{[9
,27
]}

Teipel, Stefan J. ^{[4
,14
]}

Wiltfang, Jens ^{[5
,28
,29
]}

Wolfsgruber, Steffen ^{[9
,10
]}

Yakupov, Renat ^{[3
]}

Duezel, Emrah ^{[3
,30
]}

Jessen, Frank ^{[9
,17
,31
]}

Wagner, Michael ^{[9
,10
]}

Roeske, Sandra ^{[9
]}

Wirth, Miranka ^{[1
]}

DELCODE Study Grp

机构：

[1] German Ctr Neurodegenerat Dis DZNE, Dresden, Germany

[2] Rennes Univ Hosp, Dept Neuroradiol, CHU Rennes, Rennes, France

[3] German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany

[4] German Ctr Neurodegenerat Dis DZNE, Rostock, Germany

[5] Univ Goettingen, Univ Med Ctr Goettingen, Dept Psychiat & Psychotherapy, Gottingen, Germany

[6] German Ctr Neurodegenerat Dis DZNE, Munich, Germany

[7] Ludwig Maximilians Univ LMU Munich, Univ Hosp, Inst Stroke & Dementia Res, Munich, Germany

[8] Georg August Univ Goettingen, Dept Cognit Neurol, Magnet Resonance MR Res Neurosci, Gottingen, Germany

[9] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[10] Univ Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Med Ctr, Bonn, Germany

[11] Charite Univ Med Berlin, Dept Psychiat & Neurosci, Berlin, Germany

[12] German Ctr Neurodegenerat Dis DZNE, Berlin, Germany

[13] Charite Univ Med Berlin, Berlin Ctr Adv Neuroimaging, Berlin, Germany

[14] Rostock Univ, Med Ctr, Dept Psychosomat Med, Rostock, Germany

[15] German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany

[16] Univ Tubingen, Hertie Inst Clin Brain Res, Dept Psychiat & Psychotherapy, Sect Dementia Res, Tubingen, Germany

[17] Univ Cologne, Med Fac, Dept Psychiat, Cologne, Germany

[18] Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany

[19] Ludwig Maximilians Univ LMU Munich, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany

[20] Munich Cluster Syst Neurol SyNergy, Munich, Germany

[21] Imperial Coll London, Sch Publ Hlth, Ageing Epidemiol Res Unit AGE, London, England

[22] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Berlin, Germany

[23] Tech Univ Munich, Sch Med, Dept Psychiat & Psychotherapy, Munich, Germany

[24] Univ Edinburgh, Edinburgh, Scotland

[25] United Kingdom Dementia Res Inst UK DRI, Edinburgh, Scotland

[26] Univ Tubingen, Dept Biomed Magnet Resonance, Tubingen, Germany

[27] Univ Bonn, Dept Neurol, Bonn, Germany

[28] German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany

[29] Univ Aveiro, Inst Biomed iBiMED, Dept Med Sci, Neurosci & Signaling Grp, Aveiro, Portugal

[30] Otto von Guericke Univ, Inst Cognit Neurol & Dementia Res IKND, Magdeburg, Germany

[31] Univ Cologne, Excellence Cluster Cellular Stress Responses Aging, Cologne, Germany

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2023年 / 15卷

关键词：

multimodal leisure activities; brain reserve; brain plasticity; memory; prevention; Alzheimer's disease; WHITE-MATTER; ALZHEIMERS-DISEASE; LEISURE ACTIVITIES; HUMAN BRAIN; COGNITIVE IMPAIRMENT; FIBER TRACTS; LIFE; DEMENTIA; MEMORY; DECLINE;

D O I：

10.3389/fnagi.2023.1170879

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

BackgroundSustained environmental enrichment (EE) through a variety of leisure activities may decrease the risk of developing Alzheimer's disease. This cross-sectional cohort study investigated the association between long-term EE in young adulthood through middle life and microstructure of fiber tracts associated with the memory system in older adults.MethodsN = 201 cognitively unimpaired participants (& GE; 60 years of age) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) baseline cohort were included. Two groups of participants with higher (n = 104) or lower (n = 97) long-term EE were identified, using the self-reported frequency of diverse physical, intellectual, and social leisure activities between the ages 13 to 65. White matter (WM) microstructure was measured by fractional anisotropy (FA) and mean diffusivity (MD) in the fornix, uncinate fasciculus, and parahippocampal cingulum using diffusion tensor imaging. Long-term EE groups (lower/higher) were compared with adjustment for potential confounders, such as education, crystallized intelligence, and socio-economic status.ResultsReported participation in higher long-term EE was associated with greater fornix microstructure, as indicated by higher FA (standardized & beta; = 0.117, p = 0.033) and lower MD (& beta; = -0.147, p = 0.015). Greater fornix microstructure was indirectly associated (FA: unstandardized B = 0.619, p = 0.038; MD: B = -0.035, p = 0.026) with better memory function through higher long-term EE. No significant effects were found for the other WM tracts.ConclusionOur findings suggest that sustained participation in a greater variety of leisure activities relates to preserved WM microstructure in the memory system in older adults. This could be facilitated by the multimodal stimulation associated with the engagement in a physically, intellectually, and socially enriched lifestyle. Longitudinal studies will be needed to support this assumption.

引用

页数：12

共 82 条

[71]

Tingley D, 2014, J STAT SOFTW, V59

[72] A Review of Combined Training Studies in Older Adults According to a New Categorization of Conventional Interventions [J].

Torre, Marta Maria ;

Temprado, Jean-Jacques .

FRONTIERS IN AGING NEUROSCIENCE, 2022, 13

[73]

Tromp D., 2016, The Winnower, DOI DOI 10.15200/WINN.146228.88496

[74] Assessment of complex mental activity across the lifespan: development of the Lifetime of Experiences Questionnaire (LEQ) [J].

Valenzuela, Michael J. ;

Sachdev, Perminder .

PSYCHOLOGICAL MEDICINE, 2007, 37 (07) :1015-1025

[75] Leisure activities and the risk of dementia in the elderly [J].

Verghese, J ;

Lipton, RB ;

Katz, MJ ;

Hall, CB ;

Derby, CA ;

Kuslansky, G ;

Ambrose, AF ;

Sliwinski, M ;

Buschke, H .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (25) :2508-2516

[76] Music Making as a Tool for Promoting Brain Plasticity across the Life Span [J].

Wan, Catherine Y. ;

Schlaug, Gottfried .

NEUROSCIENTIST, 2010, 16 (05) :566-577

[77] Enhanced Learning through Multimodal Training: Evidence from a Comprehensive Cognitive, Physical Fitness, and Neuroscience Intervention [J].

Ward, N. ;

Paul, E. ;

Watson, P. ;

Cooke, G. E. ;

Hillman, C. H. ;

Cohen, N. J. ;

Kramer, A. F. ;

Barbey, A. K. .

SCIENTIFIC REPORTS, 2017, 7

[78]

Wickham H., 2016, ggplot2: Elegant Graphics for Data Analysis, DOI DOI 10.1007/978-3-319-24277-4

[79] Neuroprotective pathways: lifestyle activity, brain pathology, and cognition in cognitively normal older adults [J].

Wirth, Miranka ;

Haase, Claudia M. ;

Villeneuve, Sylvia ;

Vogel, Jacob ;

Jagust, William J. .

NEUROBIOLOGY OF AGING, 2014, 35 (08) :1873-1882

[80] Minor neuropsychological deficits in patients with subjective cognitive decline [J].

Wolfsgruber, Steffen ;

Kleineidam, Luca ;

Guski, Jannis ;

Polcher, Alexandra ;

Frommann, Ingo ;

Roeske, Sandra ;

Spruth, Eike Jakob ;

Franke, Christiana ;

Priller, Josef ;

Kilimann, Ingo ;

Teipel, Stefan ;

Buerger, Katharina ;

Janowitz, Daniel ;

Laske, Christoph ;

Buchmann, Martina ;

Peters, Oliver ;

Menne, Felix ;

Fuentes Casan, Manuel ;

Wiltfang, Jens ;

Bartels, Claudia ;

Duezel, Emrah ;

Metzger, Coraline ;

Glanz, Wenzel ;

Thelen, Manuela ;

Spottke, Annika ;

Ramirez, Alfredo ;

Kofler, Barbara ;

Fliessbach, Klaus ;

Schneider, Anja ;

Heneka, Michael T. ;

Brosseron, Frederic ;

Meiberth, Dix ;

Jessen, Frank ;

Wagner, Michael .

NEUROLOGY, 2020, 95 (09) :E1134-E1143

← 1 2 3 4 5 6 7 8 9 →