Long-term environmental enrichment is associated with better fornix microstructure in older adults

被引：4

作者：

Klimecki, Olga M. ^{[1
]}

Liebscher, Maxie ^{[1
]}

Gaubert, Malo ^{[1
,2
]}

Hayek, Dayana ^{[3
]}

Zarucha, Alexis ^{[1
]}

Dyrba, Martin ^{[4
]}

Bartels, Claudia ^{[5
]}

Buerger, Katharina ^{[6
,7
]}

Butryn, Michaela ^{[3
]}

Dechent, Peter ^{[8
]}

Dobisch, Laura ^{[3
]}

Ewers, Michael ^{[6
,7
]}

Fliessbach, Klaus ^{[9
,10
]}

Freiesleben, Silka Dawn ^{[11
,12
]}

Glanz, Wenzel ^{[3
]}

Hetzer, Stefan ^{[13
]}

Janowitz, Daniel ^{[7
]}

Kilimann, Ingo ^{[4
,14
]}

Kleineidam, Luca ^{[9
,10
]}

Laske, Christoph ^{[15
,16
]}

Maier, Franziska ^{[17
]}

Munk, Matthias H. ^{[15
,18
]}

Perneczky, Robert ^{[6
,19
,20
,21
]}

Peters, Oliver ^{[11
,12
]}

Priller, Josef ^{[12
,22
,23
,24
,25
]}

Rauchmann, Boris-Stephan ^{[19
]}

Roy, Nina ^{[9
]}

Scheffler, Klaus ^{[26
]}

Schneider, Anja ^{[9
,10
]}

Spruth, Eike Jakob ^{[11
,12
]}

Spottke, Annika ^{[9
,27
]}

Teipel, Stefan J. ^{[4
,14
]}

Wiltfang, Jens ^{[5
,28
,29
]}

Wolfsgruber, Steffen ^{[9
,10
]}

Yakupov, Renat ^{[3
]}

Duezel, Emrah ^{[3
,30
]}

Jessen, Frank ^{[9
,17
,31
]}

Wagner, Michael ^{[9
,10
]}

Roeske, Sandra ^{[9
]}

Wirth, Miranka ^{[1
]}

DELCODE Study Grp

机构：

[1] German Ctr Neurodegenerat Dis DZNE, Dresden, Germany

[2] Rennes Univ Hosp, Dept Neuroradiol, CHU Rennes, Rennes, France

[3] German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany

[4] German Ctr Neurodegenerat Dis DZNE, Rostock, Germany

[5] Univ Goettingen, Univ Med Ctr Goettingen, Dept Psychiat & Psychotherapy, Gottingen, Germany

[6] German Ctr Neurodegenerat Dis DZNE, Munich, Germany

[7] Ludwig Maximilians Univ LMU Munich, Univ Hosp, Inst Stroke & Dementia Res, Munich, Germany

[8] Georg August Univ Goettingen, Dept Cognit Neurol, Magnet Resonance MR Res Neurosci, Gottingen, Germany

[9] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[10] Univ Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Med Ctr, Bonn, Germany

[11] Charite Univ Med Berlin, Dept Psychiat & Neurosci, Berlin, Germany

[12] German Ctr Neurodegenerat Dis DZNE, Berlin, Germany

[13] Charite Univ Med Berlin, Berlin Ctr Adv Neuroimaging, Berlin, Germany

[14] Rostock Univ, Med Ctr, Dept Psychosomat Med, Rostock, Germany

[15] German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany

[16] Univ Tubingen, Hertie Inst Clin Brain Res, Dept Psychiat & Psychotherapy, Sect Dementia Res, Tubingen, Germany

[17] Univ Cologne, Med Fac, Dept Psychiat, Cologne, Germany

[18] Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany

[19] Ludwig Maximilians Univ LMU Munich, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany

[20] Munich Cluster Syst Neurol SyNergy, Munich, Germany

[21] Imperial Coll London, Sch Publ Hlth, Ageing Epidemiol Res Unit AGE, London, England

[22] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Berlin, Germany

[23] Tech Univ Munich, Sch Med, Dept Psychiat & Psychotherapy, Munich, Germany

[24] Univ Edinburgh, Edinburgh, Scotland

[25] United Kingdom Dementia Res Inst UK DRI, Edinburgh, Scotland

[26] Univ Tubingen, Dept Biomed Magnet Resonance, Tubingen, Germany

[27] Univ Bonn, Dept Neurol, Bonn, Germany

[28] German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany

[29] Univ Aveiro, Inst Biomed iBiMED, Dept Med Sci, Neurosci & Signaling Grp, Aveiro, Portugal

[30] Otto von Guericke Univ, Inst Cognit Neurol & Dementia Res IKND, Magdeburg, Germany

[31] Univ Cologne, Excellence Cluster Cellular Stress Responses Aging, Cologne, Germany

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2023年 / 15卷

关键词：

multimodal leisure activities; brain reserve; brain plasticity; memory; prevention; Alzheimer's disease; WHITE-MATTER; ALZHEIMERS-DISEASE; LEISURE ACTIVITIES; HUMAN BRAIN; COGNITIVE IMPAIRMENT; FIBER TRACTS; LIFE; DEMENTIA; MEMORY; DECLINE;

D O I：

10.3389/fnagi.2023.1170879

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

BackgroundSustained environmental enrichment (EE) through a variety of leisure activities may decrease the risk of developing Alzheimer's disease. This cross-sectional cohort study investigated the association between long-term EE in young adulthood through middle life and microstructure of fiber tracts associated with the memory system in older adults.MethodsN = 201 cognitively unimpaired participants (& GE; 60 years of age) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) baseline cohort were included. Two groups of participants with higher (n = 104) or lower (n = 97) long-term EE were identified, using the self-reported frequency of diverse physical, intellectual, and social leisure activities between the ages 13 to 65. White matter (WM) microstructure was measured by fractional anisotropy (FA) and mean diffusivity (MD) in the fornix, uncinate fasciculus, and parahippocampal cingulum using diffusion tensor imaging. Long-term EE groups (lower/higher) were compared with adjustment for potential confounders, such as education, crystallized intelligence, and socio-economic status.ResultsReported participation in higher long-term EE was associated with greater fornix microstructure, as indicated by higher FA (standardized & beta; = 0.117, p = 0.033) and lower MD (& beta; = -0.147, p = 0.015). Greater fornix microstructure was indirectly associated (FA: unstandardized B = 0.619, p = 0.038; MD: B = -0.035, p = 0.026) with better memory function through higher long-term EE. No significant effects were found for the other WM tracts.ConclusionOur findings suggest that sustained participation in a greater variety of leisure activities relates to preserved WM microstructure in the memory system in older adults. This could be facilitated by the multimodal stimulation associated with the engagement in a physically, intellectually, and socially enriched lifestyle. Longitudinal studies will be needed to support this assumption.

引用

页数：12

共 82 条

[1] A systematic review and meta-analysis of structural magnetic resonance imaging studies investigating cognitive and social activity levels in older adults
Anaturk, M.
Demnitz, N.
Ebmeier, K. P.
Sexton, C. E.
[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2018, 93 : 71 - 84
[2] Hippocampal Pathway Plasticity Is Associated with the Ability to Form Novel Memories in Older Adults
Antonenko, Darla
Kuelzow, Nadine
Cesarz, Magda E.
Schindler, Kristina
Grittner, Ulrike
Floeel, Agnes
[J]. FRONTIERS IN AGING NEUROSCIENCE, 2016, 8
[3] Bundle-specific associations between white matter microstructure and Ab and tau pathology in preclinical Alzheimer's disease
Binette, Alexa Pichet
Theaud, Guillaume
Rheault, Francois
Roy, Maggie
Collins, D. Louis
Levin, Johannes
Mori, Hiroshi
Lee, Jae Hong
Farlow, Martin Rhys
Schofield, Peter
Chhatwal, Jasmeer P.
Masters, Colin L.
Benzinger, Tammie
Morris, John
Bateman, Randall
Breitner, John Cs
Poirier, Judes
Gonneaud, Julie
Descoteaux, Maxime
Villeneuve, Sylvia
[J]. ELIFE, 2021, 10
[4] Musical Activity During Life Is Associated With Multi-Domain Cognitive and Brain Benefits in Older Adults
Boettcher, Adriana
Zarucha, Alexis
Koebe, Theresa
Gaubert, Malo
Hoeppner, Angela
Altenstein, Slawek
Bartels, Claudia
Buerger, Katharina
Dechent, Peter
Dobisch, Laura
Ewers, Michael
Fliessbach, Klaus
Freiesleben, Silka Dawn
Frommann, Ingo
Haynes, John Dylan
Janowitz, Daniel
Kilimann, Ingo
Kleineidam, Luca
Laske, Christoph
Maier, Franziska
Metzger, Coraline
Munk, Matthias H. J.
Perneczky, Robert
Peters, Oliver
Priller, Josef
Rauchmann, Boris-Stephan
Roy, Nina
Scheffler, Klaus
Schneider, Anja
Spottke, Annika
Teipel, Stefan J.
Wiltfang, Jens
Wolfsgruber, Steffen
Yakupov, Renat
Duezel, Emrah
Jessen, Frank
Roeske, Sandra
Wagner, Michael
Kempermann, Gerd
Wirth, Miranka
[J]. FRONTIERS IN PSYCHOLOGY, 2022, 13
[5] Structural integrity in subjective cognitive decline, mild cognitive impairment and Alzheimer's disease based on multicenter diffusion tensor imaging
Brueggen, Katharina
Dyrba, Martin
Cardenas-Blanco, Arturo
Schneider, Anja
Fliessbach, Klaus
Buerger, Katharina
Janowitz, Daniel
Peters, Oliver
Menne, Felix
Priller, Josef
Spruth, Eike
Wiltfang, Jens
Vukovich, Ruth
Laske, Christoph
Buchmann, Martina
Wagner, Michael
Roeske, Sandra
Spottke, Annika
Rudolph, Janna
Metzger, Coraline D.
Kilimann, Ingo
Dobisch, Laura
Dueze, Emrah
Jessen, Frank
Teipel, Stefan J.
[J]. JOURNAL OF NEUROLOGY, 2019, 266 (10) : 2465 - 2474
[6] White matter fiber tracts of the human brain:: Three-dimensional mapping at microscopic resolution, topography and intersubject variability
Bürgel, U
Amunts, K
Hoemke, L
Mohlberg, H
Gilsbach, JM
Zilles, K
[J]. NEUROIMAGE, 2006, 29 (04) : 1092 - 1105
[7] White Matter Integrity Declined Over 6-Months, but Dance Intervention Improved Integrity of the Fornix of Older Adults
Burzynska, Agnieszka Z.
Jiao, Yuqin
Knecht, Anya M.
Fanning, Jason
Awick, Elizabeth A.
Chen, Tammy
Gothe, Neha
Voss, Michelle W.
McAuley, Edward
Kramer, Arthur F.
[J]. FRONTIERS IN AGING NEUROSCIENCE, 2017, 9
[8] Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation, and late-life activities
Chan, Dennis
Shafto, Meredith
Kievit, Rogier
Matthews, Fiona
Spink, Molly
Valenzuela, Michael
Henson, Rik N.
[J]. NEUROBIOLOGY OF AGING, 2018, 70 : 180 - 183
[9] Clift S., 2019, Nordic Journal of Arts, Culture and Health, V2, P77, DOI DOI 10.18261/ISSN.2535-7913-2020-01-08
[10] Association Between Components of Cognitive Reserve and Serum BDNF in Healthy Older Adults
Collins, Jessica M.
Hill, Edward
Bindoff, Aidan
King, Anna E.
Alty, Jane
Summers, Mathew J.
Vickers, James C.
[J]. FRONTIERS IN AGING NEUROSCIENCE, 2021, 13

← 1 2 3 4 5 6 7 8 9 →