Differential target multiplexed spinal cord stimulator: a review of preclinical/clinical data and hardware advancement

被引：3
作者：
Murphy, Melissa Z. [1 ]
Fishman, Michael A. [2 ]
机构：
[1] North Texas Orthoped & Spine Ctr, Grapevine, TX 76051 USA
[2] Ctr Intervent Pain & Spine, Lancaster, PA 17604 USA
来源：
PAIN MANAGEMENT | 2023年 / 13卷 / 04期
关键词：
back pain; differential target multiplexed; glial cells; Intellis (TM); spinal cord stimulator; RANDOMIZED CONTROLLED-TRIAL; CHRONIC PAIN; NEUROMODULATION; SURGERY; THERAPY; SYSTEM; BACK;
D O I：
10.2217/pmt-2022-0052
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Spinal cord stimulation (SCS) is an effective neuromodulation technique for treating chronic neuropathic pain. Recent rapid growth in understanding its mechanism has led to the development of glial cell-based differential target multiplexed (DTM) stimulation and its derivative algorithm. Both preclinical research and clinical trials in humans showed superior pain relief using DTM SCS compared with traditional SCS. Another multicenter prospective clinical trial showed significant pain score reduction and energy saving using the DTM derivative algorithm. This review paper summarizes the evidence related to using DTM stimulation for other painful conditions such as nonsurgical low back pain and upper-limb pain. All these advanced programming options can be delivered using an innovative platform, the Medtronic Intellis (TM) neurostimulator.
引用
收藏
页码：233 / 242
页数：10
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