Non-Viral Nucleic Acid Delivery System for RNA Therapeutics

被引：4
作者：
Liu, Lianxiao [1 ]
Zhou, Yiming [1 ]
Xu, Anqiu [1 ]
Wang, Chenglong [1 ]
Li, Ning [1 ]
Huang, Hongwei [1 ,2 ,3 ]
Zhang, Yuntao [4 ]
Yang, Xiaoming [4 ]
机构：
[1] China Natl Biol Grp Virogin Biotech Shanghai Ltd, CNBG Virogin, Shanghai 201802, Peoples R China
[2] Virogin Biotech Shanghai Ltd, Shanghai 201802, Peoples R China
[3] Virogin Biotech Canada Ltd, Richmond, ON V6V1A8, Canada
[4] China Natl Biotech Grp CNBG, Beijing 100024, Peoples R China
来源：
ADVANCED THERAPEUTICS | 2023年 / 6卷 / 08期
关键词：
drug delivery; gene therapy; nanotechnology; nucleic acid; vectors; RNA therapeutics; NEGATIVE BREAST-CANCER; LIPID NANOPARTICLES; DRUG-DELIVERY; MESSENGER-RNA; GENE DELIVERY; IN-VIVO; MEDIATED DELIVERY; SIRNA DELIVERY; ASIALOGLYCOPROTEIN RECEPTOR; TARGETED DELIVERY;
D O I：
10.1002/adtp.202300005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nucleic acid drugs can treat diseases caused by defective or abnormal genes. Herein, the mechanism of non-viral vectors for nucleic acid drug delivery is described. This review introduce non-viral vectors for nucleic acid drug delivery, including the nucleic acid-carrier conjugate, proteins and peptides-based nanoparticles, polysaccharides, and other biological macromolecules-based nanoparticles consisting of lipid nanoparticles, synthetic polymers-based nanoparticles, inorganic nanoparticles, and organic-inorganic hybrid nanoparticles. Finally, the challenges and prospects of non-viral vectors for nucleic acid drug delivery are discussed.
引用
收藏
页数：23
相关论文
共 244 条
[61]   Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research [J].
Gehl, J .
ACTA PHYSIOLOGICA SCANDINAVICA, 2003, 177 (04) :437-447
[62]   Co-delivery of curcumin and Bcl-2 siRNA by PAMAM dendrimers for enhancement of the therapeutic efficacy in HeLa cancer cells [J].
Ghaffari, Maryam ;
Dehghan, Gholamreza ;
Baradaran, Behzad ;
Zarebkohan, Amir ;
Mansoori, Behzad ;
Soleymani, Jafar ;
Dolatabadi, Jafar Ezzati Nazhad ;
Hamblin, Michael R. .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2020, 188
[63]   Poly(lysine) Dendrimers Form Complexes with siRNA and Provide Its Efficient Uptake by Myeloid Cells: Model Studies for Therapeutic Nucleic Acid Delivery [J].
Gorzkiewicz, Michal ;
Kopec, Olga ;
Janaszewska, Anna ;
Konopka, Malgorzata ;
Pedziwiatr-Werbicka, Elzbieta ;
Tarasenko, Irina I. ;
Bezrodnyi, Valeriy V. ;
Neelov, Igor M. ;
Klajnert-Maculewicz, Barbara .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (09)
[64]  
GOU Z, 2020, ORG ELECTRON, V20, P1
[65]   Efficient generation of targeted large insertions by microinjection into two-cell-stage mouse embryos [J].
Gu, Bin ;
Posfai, Eszter ;
Rossant, Janet .
NATURE BIOTECHNOLOGY, 2018, 36 (07) :632-+
[66]   Self-assembled peptide-poloxamine nanoparticles enable in vitro and in vivo genome restoration for cystic fibrosis [J].
Guan, Shan ;
Munder, Antje ;
Hedtfeld, Silke ;
Braubach, Peter ;
Glage, Silke ;
Zhang, Longgui ;
Lienenklaus, Stefan ;
Schultze, Anja ;
Hasenpusch, Guenther ;
Garrels, Wiebke ;
Stanke, Frauke ;
Miskey, Csaba ;
Johler, Sarah M. ;
Kumar, Yadhu ;
Tuemmler, Burkhard ;
Rudolph, Carsten ;
Ivics, Zoltan ;
Rosenecker, Joseph .
NATURE NANOTECHNOLOGY, 2019, 14 (03) :287-+
[67]   Chemical Protein Modification through Cysteine [J].
Gunnoo, Smita B. ;
Madder, Annemieke .
CHEMBIOCHEM, 2016, 17 (07) :529-553
[68]  
Guo S., 2022, PROCEEDING IEEE INT, P543
[69]   Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy [J].
Guo, Sijin ;
Vieweger, Mario ;
Zhang, Kaiming ;
Yin, Hongran ;
Wang, Hongzhi ;
Li, Xin ;
Li, Shanshan ;
Hu, Shuiying ;
Sparreboom, Alex ;
Evers, B. Mark ;
Dong, Yizhou ;
Chiu, Wah ;
Guo, Peixuan .
NATURE COMMUNICATIONS, 2020, 11 (01)
[70]   Novel mechanism of gene transfection by low-energy shock wave [J].
Ha, Chang Hoon ;
Lee, Seok Cheol ;
Kim, Sunghyen ;
Chung, Jihwa ;
Bae, Hasuk ;
Kwon, Kihwan .
SCIENTIFIC REPORTS, 2015, 5
234567891011