Non-Viral Nucleic Acid Delivery System for RNA Therapeutics

被引：4

作者：

Liu, Lianxiao ^{[1
]}

Zhou, Yiming ^{[1
]}

Xu, Anqiu ^{[1
]}

Wang, Chenglong ^{[1
]}

Li, Ning ^{[1
]}

Huang, Hongwei ^{[1
,2
,3
]}

Zhang, Yuntao ^{[4
]}

Yang, Xiaoming ^{[4
]}

机构：

[1] China Natl Biol Grp Virogin Biotech Shanghai Ltd, CNBG Virogin, Shanghai 201802, Peoples R China

[2] Virogin Biotech Shanghai Ltd, Shanghai 201802, Peoples R China

[3] Virogin Biotech Canada Ltd, Richmond, ON V6V1A8, Canada

[4] China Natl Biotech Grp CNBG, Beijing 100024, Peoples R China

来源：

ADVANCED THERAPEUTICS | 2023年 / 6卷 / 08期

关键词：

drug delivery; gene therapy; nanotechnology; nucleic acid; vectors; RNA therapeutics; NEGATIVE BREAST-CANCER; LIPID NANOPARTICLES; DRUG-DELIVERY; MESSENGER-RNA; GENE DELIVERY; IN-VIVO; MEDIATED DELIVERY; SIRNA DELIVERY; ASIALOGLYCOPROTEIN RECEPTOR; TARGETED DELIVERY;

D O I：

10.1002/adtp.202300005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nucleic acid drugs can treat diseases caused by defective or abnormal genes. Herein, the mechanism of non-viral vectors for nucleic acid drug delivery is described. This review introduce non-viral vectors for nucleic acid drug delivery, including the nucleic acid-carrier conjugate, proteins and peptides-based nanoparticles, polysaccharides, and other biological macromolecules-based nanoparticles consisting of lipid nanoparticles, synthetic polymers-based nanoparticles, inorganic nanoparticles, and organic-inorganic hybrid nanoparticles. Finally, the challenges and prospects of non-viral vectors for nucleic acid drug delivery are discussed.

引用

页数：23

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