The effect of vitamin C on the risk of mortality in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials

被引：7

作者：

Kow, Chia Siang ^{[1
]}

Hasan, Syed Shahzad ^{[2
,3
]}

Ramachandram, Dinesh Sangarran ^{[4
]}

机构：

[1] Int Med Univ, Sch Pharm, 126 Jalan Jalil Perkasa, Kuala Lumpur, Malaysia

[2] Univ Huddersfield, Sch Appl Sci, Huddersfield, England

[3] Univ Newcastle, Sch Biomed Sci & Pharm, Callaghan, Australia

[4] Monash Univ Malaysia, Sch Pharm, Bandar Sunway, Selangor, Malaysia

来源：

INFLAMMOPHARMACOLOGY | 2023年 / 31卷 / 06期

关键词：

Ascorbic acid; COVID-19; Mortality; Vitamin C; BLIND;

D O I：

10.1007/s10787-023-01200-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background and AimsVitamin C appears to be a viable treatment option for patients with COVID-19.MethodsWe conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) of vitamin C versus comparative interventions in patients with COVID-19. The outcome of interest was all-cause mortality.Results The meta-analysis of eleven trials using a random-effects model revealed significant reduction in the risk of all-cause mortality with the administration of vitamin C among patients with COVID-19 relative to no vitamin C (pooled odds ratio = 0.53; 95% confidence interval 0.30-0.92). Subgroup analysis of studies that included patients with severe COVID-19 also produced findings of significant mortality reduction with the administration of vitamin C relative to no vitamin C (pooled odds ratio = 0.47; 95% confidence interval 0.26-0.84).Conclusion Overall, evidence from RCTs suggests a survival benefit for vitamin C in patients with severe COVID-19. However, we should await data from large-scale randomized trials to affirm its mortality benefits.

引用

页码：3357 / 3362

页数：6

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