Management of Toxicities Associated With Immune Checkpoint Inhibitors

被引：0

作者：

Yun, Karen M. ^{[1
]}

Bazhenova, Lyudmila ^{[1
]}

机构：

[1] UC San Diego Hlth, Div Hematol Oncol, Moores Canc Ctr, 3855 Hlth Sci Dr, La Jolla, CA 92093 USA

来源：

CLINICAL ADVANCES IN HEMATOLOGY & ONCOLOGY | 2023年 / 21卷 / 03期

关键词：

Immune checkpoint inhibitors (ICIs); immune-related adverse events (irAEs); immunotherapy; ADVERSE EVENTS; REFRACTORY COLITIS; MELANOMA; PNEUMONITIS; THERAPY; PATIENT;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune-related adverse events (irAEs) encompass a diverse range of toxicities following treatment with immune check-point inhibitors (ICIs), each with distinctive symptoms, severities, and outcomes. irAEs can affect any organ and are potentially fatal, so early diagnosis is key in preventing serious events. irAEs can be fulminant, requiring immediate attention and intervention. Management of irAEs involves the use of systemic corticosteroids and immunosuppressive agents in addition to any disease-specific therapeutics. Making the decision to rechallenge with ICIs is not always clear and involves weighing the risks and clinical benefits of continuing ICI therapy. Here, we review the consensus recom-mendations on managing irAEs and discuss current challenges in clinical care caused by these toxicities.

引用

页码：142 / 149

页数：8

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