Adherence to cardiovascular disease risk factor medications among patients with cancer: a systematic review

被引:9
作者
Zullig, Leah L. [1 ,2 ,3 ]
Drake, Connor [2 ]
Shahsahebi, Mohammad [3 ]
Avecilla, Renee A. V. [3 ]
Whitney, Colette [3 ]
Mills, Coleman [3 ]
Oeffinger, Kevin C. [3 ]
机构
[1] Durham Vet Affairs Hlth Care Syst, Ctr Innovat Accelerate Discovery & Practice Trans, 411 West Chapel Hill St,Suite 600, Durham, NC 27701 USA
[2] Duke Univ, Dept Populat Hlth Sci, Sch Med, Durham, NC 27708 USA
[3] Duke Canc Inst, Ctr Oncoprimary Care, Durham, NC 27710 USA
基金
美国国家卫生研究院;
关键词
Medication adherence; Cancer survivors; Cardiovascular diseases; Heart disease risk factors; SURVIVORSHIP CARE PLANS; BREAST-CANCER; PHYSICAL-ACTIVITY; MEDICARE BENEFICIARIES; PREDICTIVE-VALIDITY; HODGKIN LYMPHOMA; HEART-FAILURE; CLAIMS DATA; DRUG-USE; IMPACT;
D O I
10.1007/s11764-022-01212-0
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose The most common cause of mortality for many cancer survivors is cardiovascular disease (CVD). This requires a shift in thinking where control of CVD risk factor-related comorbidity is paramount. Our objective was to provide an understanding of adherence to medications for the management of CVD risk factor-related comorbidities among cancer survivors. Methods We systematically searched for articles indexed in MEDLINE (via PubMed), Embase, Cochrane (Wiley), PsycINFO, and Scopus (via Elsevier) for articles published from inception to October 31, 2019, and updated the search on June 7, 2021. English language, original research that assessed medication adherence to common CVD risk factor-related comorbidities among cancer survivors was included. We assessed risk of bias using the Mixed Methods Appraisal Tool. Results Of the 21 studies included, 57% focused on multiple cancer types. Seventy-one percent used pharmacy-based adherence measures. Two were prospective. Adherence was variable across cancer types and CVD risk factor-related comorbidities. Among the studies that examined changes in comorbid medication adherence, most noted a decline in adherence following cancer diagnosis and throughout cancer treatment. There was a focus on breast cancer populations. Conclusions CVD risk factor-related medication adherence is low among cancer survivors and declines over time. Given the risk for CVD-mortality among cancer survivors, testing of interventions aimed at improving adherence to non-cancer medications is critically needed. Implications for Cancer Survivors For many cancer survivors, regularly taking medications to manage CVD risk is important for longevity. Engaging with primary care throughout the cancer care trajectory may be important to support cardiovascular health.
引用
收藏
页码:595 / 618
页数:24
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