Two new triterpenes isolated from Maytenus guangxiensis C. Y. Cheng et W. L. Sha and their antiproliferative activities

被引：1

作者：

Huang, YuanYuan ^{[1
,2
]}

Chen, Lu ^{[3
]}

Yao, Jing ^{[4
]}

Jia, XueGong ^{[1
]}

Deng, FuSheng ^{[1
]}

Mo, JingYa ^{[1
]}

Yuan, JingQuan ^{[1
]}

机构：

[1] Guangxi Univ Chinese Med, Sci Expt Ctr, Nanning, Peoples R China

[2] Nanning Normal Univ, Sch Chem & Mat, Nanning, Peoples R China

[3] Guangxi Bot Garden Med Plants, Nanning, Peoples R China

[4] Guangxi Univ Chinese Med, Ctr Translat Med Res Integrat Chinese & Western M, Ruikang Hosp, Nanning, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Maytenus guangxiensis; triterpenes; antiproliferative activities; cancer cells;

D O I：

10.1080/14786419.2021.2023870

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new triterpenes, 3 beta, 7 beta-dihydroxyolean-12-en-11-one (1) and 3 beta-O-acetyl-7 beta-hydroxyolean-12-en-11-one (2), along with four known triterpenes 3 beta-hydroxyolean-12-en-11-one (3), beta-amyrin (4), lup-20(29)-ene-1 beta, 3 beta-diol (5) and 1 beta, 3 beta-dihydroxy-urs-9(11)-12-diene (6), were isolated from the stems and leaves of Maytenus guangxiensis C. Y. Cheng et W. L. Sha. Their structures were elucidated using 1D and 2D NMR spectroscopy as well as MS and IR experiments. Compounds (3-6) were isolated from M. guangxiensis for the first time. Compounds 1-6 were evaluated for their antiproliferative activities against Eca-109, PANC-1, EJ and HeLa cell lines. The results showed that compounds 1-6 displayed a certain degree of inhibitory effects against the proliferation of various human cancer cell lines.

引用

页码：1498 / 1504

页数：7

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