Recent Advancements on the Use of Exosomes as Drug Carriers for the Treatment of Glioblastoma

被引:10
作者
Galardi, Angela [1 ]
De Bethlen, Alexander [1 ]
Di Paolo, Virginia [1 ]
Lampis, Silvia [1 ]
Mastronuzzi, Angela [1 ]
Di Giannatale, Angela [1 ]
机构
[1] Bambino Gesu Pediat Hosp, Dept Pediat Hemato Oncol & Cell & Gene Therapy, IRCCS, I-00165 Rome, Italy
来源
LIFE-BASEL | 2023年 / 13卷 / 04期
关键词
glioblastoma; exosomes; therapy; MESENCHYMAL STEM-CELLS; BLOOD-BRAIN-BARRIER; EXTRACELLULAR VESICLES; GENE-EXPRESSION; GLIOMA; DELIVERY; THERAPY; INHIBIT; MICROENVIRONMENT; RECURRENCE;
D O I
10.3390/life13040964
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Glioblastoma (GBM) is the most common and aggressive cancer of the brain. Presently, GBM patients have a poor prognosis, and therapy primarily aims to extend the life expectancy of affected patients. The current treatment of GBM in adult cases and high-grade gliomas in the pediatric population involves a multimodal approach that includes surgical resection followed by simultaneous chemo/radiotherapy. Exosomes are nanoparticles that transport proteins and nucleic acids and play a crucial role in mediating intercellular communication. Recent evidence suggests that these microvesicles may be used as biological carriers and offer significant advantages in targeted therapy. Due to their inherent cell-targeting properties, circulation stability, and biocompatibility, exosomes are emerging as promising new carriers for drugs and biotherapeutics. Furthermore, these nanovesicles are a repository of potential diagnostic and prognostic markers. In this review, we focus on the therapeutic potentials of exosomes in nano-delivery and describe the latest evidence of their use as a therapeutic tool in GBM.
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页数:17
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