Pentoxifylline/Chitosan Films on Wound Healing: In Vitro/In Vivo Evaluation

被引：5

作者：

Moreira, Vandiara Martins ^{[1
,2
]}

Leite, Joandra Maisa da Silva ^{[1
,2
]}

Medeiros, Kaline de Araujo ^{[1
,2
]}

Assis, Karoll Moangella Andrade de ^{[1
,2
]}

Borges, Joyce Cordeiro ^{[1
,2
]}

Santana, Lucas Matheus Barreto ^{[1
,2
]}

Moreira, Livia Maria Coelho de Carvalho ^{[1
,2
]}

Alves, Larissa Pereira ^{[1
,2
]}

de Oliveira, Tharcia Kiara Beserra ^{[3
]}

da Silveira, Joao Walter de Souza ^{[1
,2
]}

da Silva, Dayanne Tomaz Casimiro ^{[1
,2
]}

Damasceno, Bolivar Ponciano Goulart de Lima ^{[1
,2
]}

机构：

[1] State Univ Paraiba UEPB, Grad Program Pharmaceut Sci PPGCF, BR-58429500 Campina Grande, PB, Brazil

[2] UEPB, Dept Pharm, Lab Dev & Characterizat Pharmaceut Prod LDCPF, BR-58429500 Campina Grande, PB, Brazil

[3] Univ Ctr UniFacisa, Med Sci Fac, BR-58411020 Campina Grande, PB, Brazil

来源：

PHARMACEUTICS | 2023年 / 15卷 / 04期

关键词：

pentoxifylline; films; chitosan; wound healing; dressings; OXIDATIVE STRESS; IN-VITRO; ANTIBACTERIAL; DELIVERY; RELEASE; NANOCOMPOSITES; NANOPARTICLES; FORMULATIONS; FABRICATION; CLOSURE;

D O I：

10.3390/pharmaceutics15041122

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study aimed to develop films of chitosan (CSF) associated with pentoxifylline (PTX) for healing cutaneous wounds. These films were prepared at two concentrations, F1 (2.0 mg/mL) and F2 (4.0 mg/mL), and the interactions between the materials, structural characteristics, in vitro release, and morphometric aspects of skin wounds in vivo were evaluated. The formation of the CSF film with acetic acid modifies the polymeric structure, and the PTX demonstrates interaction with the CSF, in a semi-crystalline structure, for all concentrations. The release for all films was proportional to the concentration, with two phases: a fast one of <= 2 h and a slow one of >2 h, releasing 82.72 and 88.46% of the drug after 72 h, being governed by the Fickian diffusion mechanism. The wounds of the mice demonstrate a reduction of up to 60% in the area on day 2 for F2 when compared to CSF, F1, and positive control, and this characteristic of faster healing speed for F2 continues until the ninth day with wound reduction of 85%, 82%, and 90% for CSF, F1, and F2, respectively. Therefore, the combination of CSF and PTX is effective in their formation and incorporation, demonstrating that a higher concentration of PTX accelerates skin-wound reduction.

引用

页数：18

共 90 条

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