BDNF CpG methylation and serum levels covary during alcohol withdrawal in patients with alcohol use disorder: A pilot study

被引：0
作者：
Lacroix, Aurelie [1 ,2 ]
Ramoz, Nicolas [3 ]
Girard, Murielle [1 ,2 ]
Plansont, Brigitte [1 ]
Poupon, Daphnee [4 ]
Gorwood, Philip [3 ,4 ,6 ]
Nubukpo, Philippe [1 ,2 ,5 ]
机构：
[1] Ctr Hospitalier Esquirol, Unite Rech & Innovat, Federat Rech & Innovat, Limoges, France
[2] Univ Limoges, Inst Epidemiol & Trop Neurol, Inserm U1094, IRD U270,CHU Limoges,EpiMaCT Epidemiol Chron Dis T, Limoges, France
[3] Univ Paris Cite, Inst Psychiat & Neurosci Paris, INSERM, U1266, Paris, France
[4] Sainte Anne Hosp, Clin Malad Mentales & Encephale CMME, GHU Paris Psychiat & Neurosci, Paris, France
[5] Ctr Hospitalier Esquirol, Pole Univ Addictol, Limoges, France
[6] Hop Sainte Anne, CMME, GHU Paris Psychiat & Neurosci, 100 Rue Sante, F-75014 Paris, France
来源：
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY | 2023年 / 24卷 / 09期
关键词：
Epigenetics; BDNF; alcohol use disorder; Neurotropic factor; genetic; addiction; gene-environment interaction; epigenetic; EPIGENETIC REGULATION; GENE POLYMORPHISM; DNA-METHYLATION; BRAIN; STRESS; MECHANISMS; PROMOTER;
D O I：
10.1080/15622975.2023.2242924
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
ObjectivesBrain-derived neurotrophic factor (BDNF) levels vary in various conditions including alcohol use disorder (AUD). We aimed to identify drivers of these variations.MethodsTwelve patients with AUD were assessed at hospitalisation for alcohol withdrawal and four months later. We looked for associations between the change in serum BDNF levels and (1) length of abstinence, (2) anxiety (Hamilton Anxiety Scale) and depression (Beck-Depression Inventory), (3) one functional BDNF genotype (rs6265) and (4) methylation levels of 12 CpG sites within the BDNF gene (located in exons I, IV and IX).ResultsWhile abstinence remained, serum BDNF level increased. This increase correlated with the variation of methylation levels of the BDNF gene, and more specifically of exon I. We found no significant effect of length of abstinence, rs6265, depression or anxiety on serum BDNF level.ConclusionsEpigenetic regulation of the BDNF gene may be involved in variations of BDNF blood level associated with alcohol abstinence.
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收藏
页码：854 / 859
页数：6
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