Decrease of thyroid function after ischemic stroke is related to stroke severity

被引：1

作者：

Sidorov, Evgeny ^{[1
,2
]}

Paul, Aruna ^{[1
]}

Xu, Chao ^{[3
]}

Nouh, Claire Delpirou ^{[1
]}

Chen, Allshine ^{[3
]}

Gosmanova, Albina ^{[4
,5
]}

Gosmanov, Niyaz ^{[4
,5
]}

Gordon, David Lee ^{[1
,2
]}

Baranskaya, Irina ^{[6
]}

Chainakul, Juliane ^{[1
]}

Hamilton, Robert ^{[1
]}

Mdzinarishvili, Alexander ^{[1
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Neurol, 920 Stanton L Young Blvd 2040, Oklahoma City, OK 73104 USA

[2] Oklahoma Ctr Neurosci OCNS, Dept Cell Biol, 940 Stanton L Young Blvd,BMSB-536, Oklahoma City, OK 73104 USA

[3] Univ Oklahoma, Hlth Sci Ctr, Dept Biostat & Epidemiol, 801 NE 13Th St, Oklahoma City, OK 73104 USA

[4] Univ Oklahoma, Hlth Sci Ctr, Dept Med, Sect Endocrinol Diabet & Metab, 1000 N Lincoln Blvd, Oklahoma City, OK 73104 USA

[5] VA Hosp Oklahoma City, 921 NE 13Th St,1A-126, Oklahoma City, OK 73104 USA

[6] Dept Psychiat, 920 Stanton L Young Blvd, G Rainey Williams Pavili, Oklahoma City, OK 73104 USA

来源：

THYROID RESEARCH | 2023年 / 16卷 / 01期

关键词：

Thyroid hormones; Acute ischemic stroke; Triiodothyronine; Thyroxin; Stroke severity; HORMONE;

D O I：

10.1186/s13044-023-00160-w

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundThyroid hormones are of fundamental importance for brain function. While low triiodothyronine levels during acute ischemic stroke (AIS) are associated with worse clinical outcomes, dynamics of thyroid function after AIS remains unknown. Thus, we longitudinally evaluated thyroid hormones after stroke and related them to stroke severity.MethodsWe prospectively traced thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxin (fT4) levels from the hyper-acute (within 24 h) to acute (3-5 days) and chronic (3-6 months) stages of ischemic stroke using a mixed regression model. Then, we analyzed whether stroke severity at presentation, expressed by National Institute of Health Stroke Scale (NIHSS), is associated with change in thyroid function.ResultsForty-five patients were evaluated in hyper-acute and acute stages, while 29 were followed through chronic stage. TSH levels decreased from hyper-acute (2.91 & PLUSMN; 0.65 & mu;IU/mL) to acute (2.86 & PLUSMN; 0.46 & mu;IU/mL) and chronic stages of stroke (1.93 & PLUSMN; 0.35 & mu;IU/m, p = 0.95). fT3 levels decreased from hyper-acute (2.79 & PLUSMN; 0.09 pg/ml) to acute (2.37 & PLUSMN; 0.07 pg/ml) stages, but recovered in chronic stage (2.78 & PLUSMN; 0.10 pg/ml, p < 0.01). fT4 levels decreased from hyper-acute (1.64 & PLUSMN; 0.14 ng/dl) to acute (1.13 & PLUSMN; 0.03 ng/dl) stages, and increased in the chronic stage (1.16 & PLUSMN; 0.08 ng/dl, p = 0.02). One-unit increase in presenting NIHSS was associated with 0.04-unit decrease of fT3 from hyper-acute to the acute stage (p < 0.01).ConclusionThere is a transient decrease of thyroid hormones after ischemic stroke, possibly driven by stroke severity. Larger studies are needed to validate these findings. Correction of thyroid function in acute stroke may be investigated to improve stroke outcomes.

引用

页数：6

共 18 条

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