Circular RNAs: Biogenesis, Biological Functions, and Roles in Myocardial Infarction

被引：18
作者：
Li, Jialei [1 ]
Han, Yu [1 ]
Wang, Shuang [1 ]
Wu, Xiaolei [1 ]
Cao, Jimin [1 ]
Sun, Teng [1 ]
机构：
[1] Shanxi Med Univ, Key Lab Cellular Physiol, Dept Physiol, Key Lab Cellular Physiol Shanxi Prov,Minist Educ, Taiyuan 030001, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 04期
基金：
中国国家自然科学基金;
关键词：
circular RNAs; biogenesis; cyclization form; biological functions; myocardial infarction; ISCHEMIA-REPERFUSION INJURY; GENE-EXPRESSION; TROPONIN-I; TRANSCRIPTS; APOPTOSIS; PROMOTES; BINDING; RAT;
D O I：
10.3390/ijms24044233
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Non-coding RNAs have been excavated as important cardiac function modulators and linked to heart diseases. Significant advances have been obtained in illuminating the effects of microRNAs and long non-coding RNAs. Nevertheless, the characteristics of circular RNAs are rarely mined. Circular RNAs (circRNAs) are widely believed to participate in cardiac pathologic processes, especially in myocardial infarction. In this review, we round up the biogenesis of circRNAs, briefly describe their biological functions, and summarize the latest literature on multifarious circRNAs related to new therapies and biomarkers for myocardial infarction.
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页数：18
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