Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes

被引：17
作者：
Jiang, Xiaohua [1 ]
Fielding, Lauren A. A. [2 ]
Davis, Hunter [3 ]
Carroll, William [3 ]
Lisic, Edward C. C. [3 ]
Deweese, Joseph E. E. [2 ,4 ]
机构：
[1] Vanderbilt Univ, Dept Chem, Nashville, TN 37240 USA
[2] Freed Hardeman Univ, Dept Biol Phys & Human Sci, Henderson, TN 38340 USA
[3] Tennessee Technol Univ, Dept Chem, Cookeville, TN 38505 USA
[4] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37240 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 15期
关键词：
thiosemicarbazone; topoisomerase; antitumor; bis-thiosemicarbazone; 3-AMINOPYRIDINE-2-CARBOXALDEHYDE THIOSEMICARBAZONE; RIBONUCLEOTIDE REDUCTASE; COPPER(II) COMPLEXES; II-ALPHA; ANTITUMOR-ACTIVITY; CANCER CELLS; DNA CLEAVAGE; PHASE-II; CYTOTOXICITY; MECHANISMS;
D O I：
10.3390/ijms241512010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Topoisomerases, common targets for anti-cancer therapeutics, are crucial enzymes for DNA replication, transcription, and many other aspects of DNA metabolism. The potential anti-cancer effects of thiosemicarbazones (TSC) and metal-TSC complexes have been demonstrated to target several biological processes, including DNA metabolism. Human topoisomerases were discovered among the molecular targets for TSCs, and metal-chelated TSCs specifically displayed significant inhibition of topoisomerase II. The processes by which metal-TSCs or TSCs inhibit topoisomerases are still being studied. In this brief review, we summarize the TSCs and metal-TSCs that inhibit various types of human topoisomerases, and we note some of the key unanswered questions regarding this interesting class of diverse compounds.
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页数：16
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共 56 条
[1]   Copper(II) Complexes with Highly Water-Soluble L- and D-Proline-Thiosemicarbazone Conjugates as Potential Inhibitors of Topoisomerase IIα [J].
Bacher, Felix ;
Enyedy, Eva A. ;
Nagy, Nora V. ;
Rockenbauer, Antal ;
Bognar, Gabriella M. ;
Trondl, Robert ;
Novak, Maria S. ;
Klapproth, Erik ;
Kiss, Tamas ;
Arion, Vladimir B. .
INORGANIC CHEMISTRY, 2013, 52 (15) :8895-8908
[2]   Advances in thiosemicarbazone metal complexes as anti-lung cancer agents [J].
Bai, Xian-Guang ;
Zheng, Yunyun ;
Qi, Jinxu .
FRONTIERS IN PHARMACOLOGY, 2022, 13
[3]   Mechanistic insights on the mode of action of an antiproliferative thiosemicarbazone-nickel complex revealed by an integrated chemogenomic profiling study [J].
Baruffini, Enrico ;
Ruotolo, Roberta ;
Bisceglie, Franco ;
Montalbano, Serena ;
Ottonello, Simone ;
Pelosi, Giorgio ;
Buschini, Annamaria ;
Lodi, Tiziana .
SCIENTIFIC REPORTS, 2020, 10 (01)
[4]   Synthesis and structure of [(η6-p-cymene)Ru(2-anthracen-9-ylmethylene-N- ethylhydrazinecarbothioamide)Cl]Cl; biological evaluation, topoisomerase II inhibition and reaction with DNA and human serum albumin [J].
Beckford, Floyd ;
Thessing, Jeffrey ;
Woods, Jason ;
Didion, Jacob ;
Gerasimchuk, Nikolay ;
Gonzalez-Sarrias, Antonio ;
Seeram, Navindra P. .
METALLOMICS, 2011, 3 (05) :491-502
[5]   Synthesis, characterization, DNA binding, topoisomerase inhibition, and apoptosis induction studies of a novel cobalt(III) complex with a thiosemicarbazone ligand [J].
Beebe, Stephen J. ;
Celestine, Michael J. ;
Bullock, Jimmie L. ;
Sandhaus, Shayna ;
Arca, Jessa Faye ;
Cropek, Donald M. ;
Ludvig, Tekettay A. ;
Foster, Sydney R. ;
Clark, Jasmine S. ;
Beckford, Floyd A. ;
Tano, Criszcele M. ;
Tonsel-White, Elizabeth A. ;
Gurung, Raj K. ;
Stankavich, Courtney E. ;
Tse-Dinh, Yuk-Ching ;
Jarrett, William L. ;
Holder, Alvin A. .
JOURNAL OF INORGANIC BIOCHEMISTRY, 2020, 203
[6]   Quinoline-2-carboxaldehyde thiosemicarbazones and their Cu(II) and Ni(II) complexes as topoisomerase IIa inhibitors [J].
Bisceglie, Franco ;
Musiari, Anastasia ;
Pinelli, Silvana ;
Alinovi, Rossella ;
Menozzi, Ilaria ;
Polverini, Eugenia ;
Tarasconi, Pieralberto ;
Tavone, Matteo ;
Pelosi, Giorgio .
JOURNAL OF INORGANIC BIOCHEMISTRY, 2015, 152 :10-19
[7]   Cinnamaldehyde and cuminaldehyde thiosemicarbazones and their copper(II) and nickel(II) complexes: A study to understand their biological activity [J].
Bisceglie, Franco ;
Pinelli, Silvana ;
Alinovi, Rossella ;
Goldoni, Matteo ;
Mutti, Antonio ;
Camerini, Alessandro ;
Piola, Lorenzo ;
Tarasconi, Pieralberto ;
Pelosi, Giorgio .
JOURNAL OF INORGANIC BIOCHEMISTRY, 2014, 140 :111-125
[8]   The cytotoxicity and mechanisms of 1,2-naphtoquinone thiosemicarbazone and its metal derivatives against MCF-7 human breast cancer cells [J].
Chen, JN ;
Huang, YW ;
Liu, GS ;
Afrasiabi, Z ;
Sinn, E ;
Padhye, S ;
Ma, Y .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2004, 197 (01) :40-48
[9]   Topoisomerase inhibition and albumin interaction studies of acridine-thiosemicarbazone derivatives [J].
da Silva Filho, Francivaldo Araujo ;
Souza, Thais de Freitas ;
Ribeiro, Amelia Galdino ;
Ferreira Alves, Josival Emanuel ;
de Oliveira, Jamerson Ferreira ;
Couto de Lima Souza, Tulio Ricardo ;
de Moura, Ricardo Olimpio ;
Alves de Lima, Maria do Carmo ;
de Carvalho Junior, Luiz Bezerra ;
Vitalino de Almeida, Sinara Monica .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 138 :582-589
[10]   Thiosemicarbazones and 4-thiazolidinones indole-based derivatives: Synthesis, evaluation of antiproliferative activity, cell death mechanisms and topoisomerase inhibition assay [J].
de Oliveira, Jamerson Ferreira ;
Lima, Talitha Santos ;
Vendramini-Costa, Debora Barbosa ;
Batista de Lacerda Pedrosa, Sybelle Christianne ;
Lafayette, Elizabeth Almeida ;
Ferreira da Silva, Rosali Maria ;
Vitalino de Almeida, Sinara Monica ;
de Moura, Ricardo Olimpio ;
Tasca Gois Ruiz, Ana Lucia ;
de Carvalho, Joao Ernesto ;
Alves de Lima, Maria do Carmo .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 136 :305-314
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