Gene Correction of DNMT3A:R882H in Primary Human AML Demonstrates That This Mutation Is Not Required for Disease Maintenance, but Is Associated with Increased Leukemia Stem Cell Frequency

被引：1

作者：

Koehnke, Thomas ^{[1
,2
]}

Karigane, Daiki ^{[1
,2
]}

Hilgart, Eleanor ^{[3
]}

Kayamori, Kensuke ^{[1
,2
]}

Fan, Amy C. ^{[1
,4
]}

Collins, Cailin T. ^{[1
,2
]}

Suchy, Fabian P. ^{[1
,2
]}

Rangavajhula, Athreya S. ^{[1
,4
]}

Feng, Yang ^{[1
,2
]}

Nakauchi, Yusuke ^{[1
,2
]}

Martinez-Montes, Eduardo ^{[3
]}

Koldobskiy, Michael ^{[3
]}

Feinberg, Andy ^{[3
]}

Majeti, Ravindra ^{[2
,5
]}

机构：

[1] Stanford Univ, Sch Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Canc Inst, Stanford, CA 94305 USA

[3] Johns Hopkins Univ, Sch Med, Ctr Epigenet, Baltimore, MD USA

[4] Stanford Univ, Sch Med, Stanford Canc Inst, Stanford, CA 94305 USA

[5] Stanford Univ, Stanford Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA

来源：

关键词：

D O I：

10.1182/blood-2023-186440

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页数：3