Lactational and geographical variation in the concentration of six oligosaccharides in Chinese breast milk: a multicenter study over 13?months postpartum

被引:8
作者
Liu, Shuang [1 ]
Mao, Yingyi [2 ]
Wang, Jin [1 ]
Tian, Fang [2 ]
Hill, David R. [3 ]
Xiong, Xiaoying [2 ]
Li, Xiang [2 ]
Zhao, Yanrong [2 ]
Wang, Shuo [1 ]
机构
[1] Nankai Univ, Sch Med, Tianjin Key Lab Food Sci & Hlth, Tianjin, Peoples R China
[2] Abbott Nutr Res & Dev Ctr, Shanghai, Peoples R China
[3] Abbott Nutr Res & Dev Ctr, Columbus, OH USA
关键词
human milk; oligosaccharides; variation; lactation; geography; FORMULA; INHIBITION; GROWTH;
D O I
10.3389/fnut.2023.1267287
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
IntroductionUnderstanding the variations of oligosaccharide in breast milk contribute to better study how human milk oligosaccharides (HMOs) play a role in health-promoting benefits in infants.MethodsSix abundant HMOs, 2'-fucosyllactose (2'-FL), 3-fucosyllactose (3-FL), Lacto-N-tetraose (LNT), Lacto-N-neotetraose (LNnT), 3'-sialyllactose (3'-SL) and 6'-sialyllactose (6'-SL), in breast milk collected at 0-5 days, 10-15 days, 40-45 days, 200-240 days, and 300-400 days postpartum from six locations across China were analyzed using high-performance anion-exchange chromatography-pulsed amperometric detector.ResultsThe concentration of individual HMO fluctuated dynamically during lactational stages. The median ranges of 2'-FL, 3-FL, LNT, LNnT, 3'-SL, and 6'-SL across the five lactational stages were 935-2865 mg/L, 206-1325 mg/L, 300-1473 mg/L, 32-317 mg/L, 106-228 mg/L, and 20-616 mg/L, respectively. The prominent variation was observed in the content of 6'-SL, which demonstrates a pattern of initial increase followed by a subsequent decrease. Among the five lactational stages, the transitional milk has the highest concentration, which was 31 times greater than the concentration in mature milk at 300-400 days postpartum, where the content is the lowest. Geographical location also influenced the content of HMOs. LNT and LNnT were the highest in mature milk of mothers from Lanzhou among the six sites at 40-240 days postpartum. Breast milks were categorized into two groups base on the abundance of 2'-FL (high and low). There was no significant difference in the proportions of high and low 2'-FL phenotypes among the six sites, and the percentages of high and low 2'-FL phenotypes were 79% and 21%, respectively, across all sites in China.DiscussionThis study provided a comprehensive dataset on 6 HMOs concentrations in Chinese breast milk during the extended postpartum period across a wide geographic range and stratified by high and low 2'-FL phenotypes.
引用
收藏
页数:15
相关论文
共 73 条
[1]   Human Milk Oligosaccharides Exhibit Antimicrobial and Antibiofilm Properties against Group B Streptococcus [J].
Ackerman, Dorothy L. ;
Doster, Ryan S. ;
Weitkamp, Jorn-Hendrik ;
Aronoff, David M. ;
Gaddy, Jennifer A. ;
Townsend, Steven D. .
ACS INFECTIOUS DISEASES, 2017, 3 (08) :595-605
[2]  
[Anonymous], 2003, GLOB STRAT INF YOUNG
[3]   Physiology of Consumption of Human Milk Oligosaccharides by Infant Gut-associated Bifidobacteria [J].
Asakuma, Sadaki ;
Hatakeyama, Emi ;
Urashima, Tadasu ;
Yoshida, Erina ;
Katayama, Takane ;
Yamamoto, Kenji ;
Kumagai, Hidehiko ;
Ashida, Hisashi ;
Hirose, Junko ;
Kitaoka, Motomitsu .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (40) :34583-34592
[4]   Human Milk Oligosaccharides in the Milk of Mothers Delivering Term versus Preterm Infants [J].
Austin, Sean ;
De Castro, Carlos A. ;
Sprenger, Norbert ;
Binia, Aristea ;
Affolter, Michael ;
Garcia-Rodenas, Clara L. ;
Beauport, Lydie ;
Tolsa, Jean-Francois ;
Fumeaux, Celine J. Fischer .
NUTRIENTS, 2019, 11 (06)
[5]   Temporal Change of the Content of 10 Oligosaccharides in the Milk of Chinese Urban Mothers [J].
Austin, Sean ;
De Castro, Carlos A. ;
Benet, Thierry ;
Hou, Yangfeng ;
Sun, Henan ;
Thakkar, Sagar K. ;
Vinyes-Pares, Gerard ;
Zhang, Yumei ;
Wang, Peiyu .
NUTRIENTS, 2016, 8 (06)
[6]   Human Milk Oligosaccharide Concentrations Are Associated with Multiple Fixed and Modifiable Maternal Characteristics, Environmental Factors, and Feeding Practices [J].
Azad, Meghan B. ;
Robertson, Bianca ;
Atakora, Faisal ;
Becker, Allan B. ;
Subbarao, Padmaja ;
Moraes, Theo J. ;
Mandhane, Piushkumar J. ;
Turvey, Stuart E. ;
Lefebvre, Diana L. ;
Sears, Malcolm R. ;
Bode, Lars .
JOURNAL OF NUTRITION, 2018, 148 (11) :1733-1742
[7]   Fucosylated Human Milk Oligosaccharides and N-Glycans in the Milk of Chinese Mothers Regulate the Gut Microbiome of Their Breast-Fed Infants during Different Lactation Stages [J].
Bai, Yaqiang ;
Tao, Jia ;
Zhou, Jiaorui ;
Fan, Qingjie ;
Liu, Man ;
Hu, Yuqi ;
Xu, Yao ;
Zhang, Lilong ;
Yuan, Jieli ;
Li, Wenzhe ;
Ze, Xiaolei ;
Malard, Patrice ;
Guo, Zhimou ;
Yan, Jingyu ;
Li, Ming .
MSYSTEMS, 2018, 3 (06)
[8]   The Long-Term Public Health Benefits of Breastfeeding [J].
Binns, Colin ;
Lee, MiKyung ;
Low, Wah Yun .
ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH, 2016, 28 (01) :7-14
[9]   Human milk oligosaccharides: Every baby needs a sugar mama [J].
Bode, Lars .
GLYCOBIOLOGY, 2012, 22 (09) :1147-1162
[10]   The Human Milk Oligosaccharides 3-FL, Lacto-N-Neotetraose, and LDFT Attenuate Tumor Necrosis Factor-α Induced Inflammation in Fetal Intestinal Epithelial Cells In Vitro through Shedding or Interacting with Tumor Necrosis Factor Receptor 1 [J].
Cheng, Lianghui ;
Kong, Chunli ;
Wang, Wenjia ;
Groeneveld, Andre ;
Nauta, Arjen ;
Groves, Matthew R. ;
Kiewiet, Mensiena B. G. ;
de Vos, Paul .
MOLECULAR NUTRITION & FOOD RESEARCH, 2021, 65 (07)